Amphotericin B from Streptomyces sp.

CAS 1397-89-3C47H73NO17Biochemicals & Reagents

Amphotericin B from Streptomyces sp. (CAS: 1397-89-3, C47H73NO17, MW: 924.08) is a premium quality, γ-irradiated powder antibiotic. It is recognised for its potent antifungal properties and is widely used in research to investigate calcium influx and its effects on antifungal activity, as well as its binding kinetics with sterols. Additionally, it serves as an effective antifungal supplement in tissue culture applications.

IUPAC: Fungizone

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Amphotericin B from Streptomyces sp. (C47H73NO17) — chemical structure, CAS 1397-89-3; Life Science, fine chemical supplied by Tech Serve Solutions

AntibioticsAntibiotics A to ZAntibiotics A-FAntifungalBiochemicals and ReagentsChemical Structure ClassCore BioreagentsMechanism of ActionPolyenesResearch Essentials

01 /Applications

Antifungal Research

Investigate the impact of calcium influx on antifungal activity and study the binding and kinetics of Amphotericin B with sterols in various biological systems.

Tissue Culture Supplement

Utilised as a crucial antifungal agent to prevent fungal contamination in cell cultures, ensuring the integrity of experimental models.

Biochemical Studies

Examine the interaction of Amphotericin B with cell membrane permeability, particularly its ionophore activity with sterols in phospholipid bilayers and monolayers.

02 /Properties

Molecular weight	924.08
Empirical formula	C47H73NO17
Assay	~80% (HPLC)
Form	powder
Solubility	DMF: soluble2-4 mg/mLDMSO: soluble30-40 mg/mLH2O: insoluble
Concentration	250 μg/mL in deionized water
Storage temperature	2-8°C
Application	Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, 1 and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers 2,3. It is also commonly used in tissue culture as an antifungal supplement.
Suitability	suitable for cell culture

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1397-89-3

MDL number

MFCD00877763

PubChem substance

24890749

Beilstein registry

78342

05 /Additional specifications

Quality Level	PREMIUM
Sterility	γ-irradiated

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Amphotericin B from Streptomyces sp. used for?

Amphotericin B from Streptomyces sp. is used for antifungal research, including studying calcium influx and sterol binding, and as an antifungal supplement in tissue culture. It is also used to investigate its effects on cell membrane permeability.

What are the CAS number and chemical formula for Amphotericin B from Streptomyces sp.?

The CAS number is 1397-89-3 and the chemical formula is C47H73NO17.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Amphotericin B from Streptomyces sp. at PREMIUM quality with an assay of ~80% (HPLC). TSS does not represent this product as USP, BP, or EP grade unless explicitly stated.

How should Amphotericin B be handled safely?

Handle Amphotericin B with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. Avoid inhalation of dust and contact with skin and eyes, as it may cause irritation (H315, H319, H335).

How is Amphotericin B from Streptomyces sp. packaged and shipped?

Amphotericin B from Streptomyces sp. is γ-irradiated and typically stored at 2-8°C. TSS exports fine chemicals globally, adhering to all necessary regulations for safe and secure transport.

How can I request a quote or sample?

To request a quote or sample of Amphotericin B from Streptomyces sp., please contact our sales team through the TSS website or by phone, providing your specific requirements.