Amitriptyline hydrochloride
Amitriptyline hydrochloride (CAS: 549-18-8), with the molecular formula C20H23N · HCl and a molecular weight of 313.86, is a tricyclic compound primarily utilised as a pharmaceutical intermediate. It functions by inhibiting the reuptake of norepinephrine and serotonin, and exhibits affinity for various receptors including alpha-1 adrenergic, serotonin, and muscarinic acetylcholine receptors. This chemical is supplied as a white to off-white powder.
Pharmaceutical Intermediate
Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates. Its specific pharmacological profile makes it valuable in research and development for neurological and psychiatric conditions.
Neuroscience Research
Investigates neurotransmitter transport mechanisms, particularly serotonin and norepinephrine. Useful for studying receptor binding affinities and their implications in neurobiological pathways.
Biochemical Research Tool
Serves as a reference compound in biochemical assays and studies related to biogenic amine transport inhibition and GPCR modulation.
| Molecular weight | 313.86 |
|---|---|
| Empirical formula | C20H23N · HCl |
| Assay | ≥98% (TLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | H2O: solubleethanol: soluble |
| Storage temperature | 2-8°C |
| Application | Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors. |
Hazard statements
- H301Toxic if swallowed
- H319Causes serious eye irritation
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P301IF SWALLOWED
- P305IF IN EYES
- P501Dispose of contents and container per local regulations
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-36-50/53 |
| Safety statements (S) | 26-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Amitriptyline hydrochloride used for?
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Amitriptyline hydrochloride is a tricyclic antidepressant and is used as a pharmaceutical intermediate and research tool in neuroscience and biochemical studies, particularly for investigating neurotransmitter transporters and receptor affinities.
What are the CAS number and formula for Amitriptyline hydrochloride?
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The CAS number for Amitriptyline hydrochloride is 549-18-8, and its molecular formula is C20H23N · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Amitriptyline hydrochloride with an assay of ≥98% (TLC). We do not represent this product as USP, BP, or EP grade.
How should Amitriptyline hydrochloride be handled safely?
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Amitriptyline hydrochloride is acutely toxic if swallowed (H301) and causes serious eye irritation (H319), with long-lasting effects on aquatic life (H410). Handle with appropriate personal protective equipment including eyeshields, gloves, and respiratory protection. Avoid release to the environment.
How is Amitriptyline hydrochloride packed, shipped, and exported?
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Amitriptyline hydrochloride is typically supplied as a powder and packaged according to international shipping regulations for hazardous materials. Tech Serve Solutions is a global supplier and exporter.
How can I request a quote or sample for Amitriptyline hydrochloride?
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To request a quote or sample for Amitriptyline hydrochloride, please contact our sales department via the website or by phone.
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