Amiloride hydrochloride hydrate
Amiloride hydrochloride hydrate (CAS: 2016-88-8) is a yellow powder with the empirical formula C6H8ClN7O · HCl · xH2O. It is a selective inhibitor of urokinase plasminogen activator (uPA), a T-type calcium channel blocker, and an epithelial sodium channel blocker. This compound is primarily utilised in research for its various biological activities, including its role in developing treatments for conditions such as constipation.
- IUPAC
- N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
- Synonyms
- N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
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Calcium Channel Blocker
Amiloride hydrochloride hydrate acts as a selective blocker of T-type calcium channels, making it a valuable tool in research investigating calcium channel function and related physiological processes.
Epithelial Sodium Channel Blocker
This compound is recognised for its inhibitory effects on epithelial sodium channels. Its application in research aids in understanding ion transport mechanisms within biological systems.
Urokinase Plasminogen Activator (uPA) Inhibitor
Amiloride hydrochloride hydrate serves as a selective inhibitor of urokinase plasminogen activator (uPA), offering utility in biochemical research focused on proteolysis and related pathways.
Research in Constipation Treatment
In preclinical studies, Amiloride has been investigated for its potential as an alternative treatment for constipation, highlighting its relevance in gastrointestinal research.
| Molecular weight | 266.09 (anhydrous basis) |
|---|---|
| Empirical formula | C6H8ClN7O · HCl · xH2O |
| Assay | ≥98% (TLC) |
| Form | powder |
| Colour | yellow |
| Solubility | H2O: soluble50 mg/mL, clear, yellow-green |
| Application | Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation. |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Amiloride hydrochloride hydrate used for?
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Amiloride hydrochloride hydrate is used in research as a selective T-type calcium channel blocker, an epithelial sodium channel blocker, and a selective inhibitor of urokinase plasminogen activator (uPA). It has also been studied for potential applications in treating constipation.
What are the CAS number and formula for Amiloride hydrochloride hydrate?
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The CAS number for the anhydrous form is 2016-88-8, and the empirical formula is C6H8ClN7O · HCl · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Amiloride hydrochloride hydrate with a minimum purity of ≥98% (TLC). This product is intended for research and laboratory use; TSS does not represent it as USP, BP, or EP grade.
How should Amiloride hydrochloride hydrate be handled safely?
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Amiloride hydrochloride hydrate is classified as Danger, with hazard statement H301 (Toxic if swallowed). Handling requires appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges. Refer to the Safety Data Sheet for comprehensive handling instructions.
Is Amiloride hydrochloride hydrate a controlled substance?
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The provided data does not indicate that Amiloride hydrochloride hydrate is a controlled substance.
How is Amiloride hydrochloride hydrate packed and exported?
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Amiloride hydrochloride hydrate is supplied as a yellow powder. As a supplier and exporter, Tech Serve Solutions adheres to all relevant regulations for the safe packing and international shipment of chemicals, including UN 2811 designation for transport.
How can I request a sample or quote for Amiloride hydrochloride hydrate?
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To request a sample or a quote for Amiloride hydrochloride hydrate, please contact our sales team through the website or by phone. Our experts will assist you with your requirements.
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