Aminopterin
Aminopterin (CAS: 54-62-6), with the molecular formula C19H20N8O5, is a bioactive small molecule and a potent enzyme inhibitor. It is structurally related to folic acid and acts as an antagonist. Aminopterin is primarily utilised in research settings, particularly in cell biology and biochemistry, for its role in inhibiting dihydrofolate reductase and impacting cellular proliferation.
- IUPAC
- 4-Amino-PGA,4-Aminofolic acid,4-Aminopteroyl-L-glutamic acid
- Synonyms
- 4-Amino-PGA4-Aminofolic acid4-Aminopteroyl-L-glutamic acid
Enzyme Inhibition Studies
Aminopterin serves as a research tool to investigate the function of dihydrofolate reductase (DHFR) and related enzymes. Its inhibitory properties are crucial for understanding cellular metabolism and proliferation pathways.
Cell Biology Research
This compound is employed in cell culture experiments to study the effects of folate pathway disruption. It is suitable for use in hybridoma technology for antibody production and other cell-based assays.
Biochemical Assays
Aminopterin is used in biochemical assays to determine enzyme kinetics and to screen for other compounds that may interact with the folate pathway.
| Molecular weight | 440.41 |
|---|---|
| Empirical formula | C19H20N8O5 |
| Assay | ~98% (TLC) |
| Solubility | 2 M NaOH: soluble50 mg/mL (Solutions may be stored for 1-2 days at 4°C.)DMSO: soluble (Solutions may be stored for 1-2 days at 4°C.) |
| Concentration | 50 × |
| Storage temperature | −20°C |
| Impurities tested | endotoxin, tested |
| Suitability | suitable for hybridoma |
Hazard statements
- H300Fatal if swallowed
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P264Wash thoroughly after handling
- P301IF SWALLOWED
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 61-28 |
| Safety statements (S) | 53-28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... FPGS(2356)mouse ... Fpgs(14287) |
|---|---|
| Sterility | γ-irradiated |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Aminopterin used for?
+
Aminopterin is used in research for enzyme inhibition studies, particularly targeting dihydrofolate reductase, and in cell biology research, including hybridoma technology.
What are the CAS number and formula for Aminopterin?
+
Aminopterin has the CAS number 54-62-6 and the molecular formula C19H20N8O5.
What grade and purity does Tech Serve Solutions supply for Aminopterin?
+
Tech Serve Solutions supplies Aminopterin with an assay of ~98% (TLC). We do not represent this product as USP, BP, or EP grade.
How should Aminopterin be handled safely?
+
Aminopterin is a highly toxic compound (GHS06, GHS08, Danger, H300, H360). Handle with extreme caution, using appropriate personal protective equipment including eyeshields, gloves, and a suitable respirator. Avoid exposure and ensure safe handling procedures are followed.
How is Aminopterin shipped and exported?
+
Aminopterin is shipped and exported according to international regulations for hazardous materials. Details are available upon request.
How can I request a sample or quote for Aminopterin?
+
To request a sample or quote for Aminopterin, please contact our sales team via the website or provide your details through the product page.
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents
(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis