Alkyne-PEG5-acid
Alkyne-PEG5-acid (CAS: 1245823-51-1; Formula: C14H24O7) is a valuable bifunctional linker possessing a terminal alkyne group and a carboxylic acid moiety. This unique structure enables its participation in various bioconjugation reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC). It is widely employed in chemical biology and synthesis for creating complex molecular architectures and functionalizing biomolecules. Its polyethylene glycol spacer provides hydrophilicity and can improve solubility.
- IUPAC
- Acetylene-PEG5-acid
Bioconjugation
Alkyne-PEG5-acid serves as a key reagent in bioconjugation strategies, facilitating the attachment of molecules via click chemistry. The terminal alkyne readily reacts with azides, enabling the labeling of proteins, peptides, and nucleic acids.
Drug Delivery Systems
The polyethylene glycol (PEG) chain in Alkyne-PEG5-acid enhances the water solubility and biocompatibility of conjugates, making it suitable for developing advanced drug delivery systems and targeted therapeutics.
Surface Functionalization
This linker can be used to modify surfaces, such as nanoparticles or microarrays, by immobilizing molecules through alkyne-azide click reactions. This is critical for developing diagnostic tools and biosensors.
Chemical Synthesis
In organic synthesis, Alkyne-PEG5-acid acts as a versatile building block for constructing complex molecules with precisely defined linkers. Its dual functionality allows for sequential or orthogonal conjugation.
| Molecular weight | 304.34 |
|---|---|
| Empirical formula | C14H24O7 |
| Storage temperature | −20°C |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Alkyne-PEG5-acid used for?
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Alkyne-PEG5-acid is a bifunctional linker used in bioconjugation and chemical synthesis. Its terminal alkyne group participates in click chemistry reactions (e.g., CuAAC, SPAAC) with azide-containing molecules, while its carboxylic acid group allows for amide bond formation or other functionalizations. It is particularly useful for labeling biomolecules, modifying surfaces, and in drug delivery applications due to its PEG spacer.
What is the CAS number and formula for Alkyne-PEG5-acid?
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The CAS number for Alkyne-PEG5-acid is 1245823-51-1, and its empirical formula is C14H24O7.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Alkyne-PEG5-acid as a research-grade chemical. Purity information is available on the product's Certificate of Analysis. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Alkyne-PEG5-acid be handled and stored?
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Alkyne-PEG5-acid is classified as an irritant (GHS07, Warning, H319). Handle with appropriate personal protective equipment, including gloves, eye protection, and lab coat. Avoid inhalation of dust or vapours. It should be stored at -20°C. Refer to the Safety Data Sheet (SDS) for detailed handling and safety precautions.
Is Alkyne-PEG5-acid available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Alkyne-PEG5-acid, serving customers worldwide.
How can I request a quote or sample for Alkyne-PEG5-acid?
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To request a quote or a sample of Alkyne-PEG5-acid, please contact our sales team through the TSS website or via the provided contact details, specifying the product CAS number.
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