AF-353 hydrochloride
AF-353 hydrochloride (CAS: 927887-18-1) is a chemical compound with the formula C14H17IN4O2 · HCl. This off-white to light brown powder is primarily used in cell biology research, particularly in studies involving cell signaling, neuroscience, and ion channels. It functions as a modulator for ligand-gated ion channels, specifically targeting P2X receptors. TSS supplies this compound with a minimum purity of 98% for research and development purposes.
- IUPAC
- 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride,Ro 4 hydrochloride
Ion Channel Research
AF-353 hydrochloride serves as a valuable tool for investigating the function and modulation of ion channels, especially P2X receptors, within cellular systems.
Cell Signaling Studies
This compound is utilized in research to explore complex cell signaling pathways, offering insights into the mechanisms that regulate cellular responses.
Neuroscience Research
As a modulator of ligand-gated ion channels, AF-353 hydrochloride can be employed in neuroscience to study neuronal function and neurotransmission.
Drug Discovery and Development
AF-353 hydrochloride is recognized as an approved therapeutic or drug candidate, making it relevant for preclinical research in pharmaceutical development.
| Empirical formula | C14H17IN4O2 · HCl |
|---|---|
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | off-white to light brown |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is AF-353 hydrochloride used for?
+
AF-353 hydrochloride is used in scientific research for its role as a modulator of ligand-gated ion channels, particularly P2X receptors, in areas such as cell biology, cell signaling, and neuroscience.
What is the CAS number and chemical formula for AF-353 hydrochloride?
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The CAS number for AF-353 hydrochloride is 927887-18-1, and its chemical formula is C14H17IN4O2 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies AF-353 hydrochloride with a purity of ≥98% (HPLC). This product is intended for research and development use and is not represented as USP, BP, or EP grade.
What are the safety considerations when handling AF-353 hydrochloride?
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AF-353 hydrochloride is a Warning-grade substance with hazards including H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment in a well-ventilated area. Avoid breathing dust. Ensure proper containment.
How is AF-353 hydrochloride packaged and shipped?
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AF-353 hydrochloride is typically supplied as an off-white to light brown powder and is stored at 2-8°C. TSS can export this chemical globally, adhering to all relevant shipping regulations.
How can I request a sample or quote for AF-353 hydrochloride?
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To request a sample or a quote for AF-353 hydrochloride, please contact our sales team through the website or by phone.
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