AGK2

CAS 304896-28-4C23H13Cl2N3O2Cell Biology

AGK2 (CAS: 304896-28-4), with the molecular formula C23H13Cl2N3O2 and a molecular weight of 434.27, is a potent SIRT2 inhibitor. This compound has been utilised in research to explore the consequences of SIRT2 inhibition, including the induction of cell death and a reduction in intracellular ATP levels. Notably, AGK2 demonstrates a protective effect on dopamine neurons against alpha-synuclein toxicity in models relevant to Parkinson's disease.

IUPAC: 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

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AGK2 (C23H13Cl2N3O2) — chemical structure, CAS 304896-28-4; Life Science, fine chemical supplied by Tech Serve Solutions

A-AMBioactive Small MoleculesCell Biology

01 /Applications

SIRT2 Inhibition Studies

AGK2 serves as a research tool to investigate the biological effects of inhibiting the SIRT2 enzyme. Studies have employed AGK2 to elucidate the downstream consequences of SIRT2 blockade, such as impacts on cell viability and energy metabolism.

Neuroprotection Research

In preclinical models, AGK2 has been investigated for its potential neuroprotective properties, particularly in the context of Parkinson's disease. Its demonstrated ability to rescue dopamine neurons from alpha-synuclein-induced toxicity highlights its utility in this research area.

Cell Biology Research

As a bioactive small molecule, AGK2 finds application in broader cell biology research to understand signalling pathways and cellular responses modulated by SIRT2 activity. Its effects on cell death and ATP levels offer insights into cellular regulation.

02 /Properties

Molecular weight	434.27
Empirical formula	C23H13Cl2N3O2
Assay	≥97% (HPLC)
Form	powder
Solubility	DMSO: soluble2 mg/mL, clear (warmed)H2O: insoluble
Storage temperature	room temp
Application	AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

304896-28-4

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is AGK2 used for?

AGK2 is primarily used as a SIRT2 inhibitor in research settings. It has been employed in studies to investigate cell death induction, intracellular ATP level reduction, and neuroprotection in Parkinson's disease models by rescuing dopamine neurons from alpha-synuclein toxicity.

What is the CAS number and molecular formula for AGK2?

The CAS number for AGK2 is 304896-28-4, and its molecular formula is C23H13Cl2N3O2.

What grade and purity does Tech Serve Solutions supply for AGK2?

Tech Serve Solutions supplies AGK2 with a purity of ≥97% (HPLC). This product is intended for research purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.

What are the safety considerations when handling AGK2?

AGK2 is classified with a GHS07 symbol and a Warning signal word, indicating it causes serious eye irritation (H319). When handling, it is essential to wear appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, and gloves. Handle in a well-ventilated area and avoid dust formation.

How is AGK2 typically supplied and exported by TSS?

AGK2 is supplied as a powder and is stored at room temperature. Tech Serve Solutions, as a global supplier and exporter, ensures appropriate packaging and documentation for international shipments.

How can I request a sample or quote for AGK2?

To request a sample or a quote for AGK2, please contact the Tech Serve Solutions sales team through the website or by direct inquiry, providing your specific requirements and shipping details.