ABT-418 hydrochloride
ABT-418 hydrochloride (CAS: 147388-83-8) is a potent selective ligand for neuronal nicotinic acetylcholine receptors (nAChRs). With cognitive-enhancing and anxiolytic-like effects, it has been studied as a potential therapeutic agent for Alzheimer's disease, demonstrating significantly higher potency than nicotine in rodent models. This compound is supplied as a fine chemical for research purposes.
- IUPAC
- 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
- Synonyms
- 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
Neuroscience Research
Investigate the role of nicotinic acetylcholine receptors in cognitive function and neurological disorders. ABT-418 hydrochloride serves as a valuable tool for studying nAChR subtypes and their downstream signaling pathways.
Drug Discovery and Development
Explore novel therapeutic strategies for neurodegenerative diseases such as Alzheimer's. Its potent cognitive-enhancing properties make it a candidate for preclinical research into treatments for memory impairment.
Pharmacological Studies
Characterise the anxiolytic-like activity and receptor binding profiles of nAChR ligands. ABT-418 hydrochloride allows for detailed investigation into its interactions with the central nervous system.
| Molecular weight | 202.68 |
|---|---|
| Empirical formula | C9H14N2O · HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Solubility | H2O: soluble15 mg/mL |
| Application | ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer’s disease. |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 7/9-22-28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Storage Condition | desiccated |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is ABT-418 hydrochloride used for?
+
ABT-418 hydrochloride is primarily used in research settings to study neuronal nicotinic acetylcholine receptors, cognitive enhancement, and anxiolytic-like activity, with potential applications in understanding and developing treatments for conditions like Alzheimer's disease.
What is the CAS number and formula for ABT-418 hydrochloride?
+
The CAS number for ABT-418 hydrochloride is 147388-83-8, and its empirical formula is C9H14N2O · HCl.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies ABT-418 hydrochloride with an assay of ≥98% by HPLC. We do not represent this product as USP, BP, or EP grade.
How should ABT-418 hydrochloride be handled?
+
ABT-418 hydrochloride is classified as Danger with hazards H300 (Fatal if swallowed), H310 (Fatal in contact with skin), and H330 (Fatal if inhaled). Handle with extreme caution in a well-ventilated area or fume hood, wearing appropriate personal protective equipment, including respiratory protection.
Is ABT-418 hydrochloride available for international export?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including ABT-418 hydrochloride.
How can I request a quote or sample of ABT-418 hydrochloride?
+
Please contact our sales team via the website or email to request a quote or sample of ABT-418 hydrochloride.
▶ Related products
(−)-Curcumol
C15H24O2
Cell Biology
(±) Clopidogrel hydrogensulfate
Cell Biology
(±)-L-Alliin
C6H11NO3S
Cell Biology
(±)-2-Amino-4-phosphonobutyric acid
C4H10NO5P
Cell Biology
(±)-2-Methylarachidonoyl-2′-fluoroethylamide
C23H38NOF
Cell Biology
(±)-3,4-Methylenedioxy-N-ethylamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxyamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxymethamphetamine hydrochloride
Cell Biology
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis