9-cis-Retinoic acid

CAS 5300-03-8C20H28O2Biochemicals & Reagents

9-cis-Retinoic acid (CAS: 5300-03-8; Formula: C20H28O2; Molar Mass: 300.44 g/mol) is a biologically active molecule and a form of Vitamin A. This retinoid plays a crucial role in cell differentiation, proliferation, and apoptosis. It is widely utilised in biological research, particularly in studies concerning gene regulation, cancer research, and cell signalling.

IUPAC: 9-cis-Tretinoin,Alitretinoin
Synonyms: Alitretinoin9-cis-Tretinoin

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9-cis-Retinoic acid (C20H28O2) — chemical structure, CAS 5300-03-8; Life Science, fine chemical supplied by Tech Serve Solutions

Antitumor AgentsBioactive Small MoleculesBiochemicals and ReagentsCancer ResearchCell BiologyGene RegulationIsoprenoidsLipidsNutrition ResearchPPAR and RXR Regulators

01 /Applications

Cancer Research

9-cis-Retinoic acid is investigated for its potential role in cancer therapy due to its influence on cell differentiation and apoptosis. It is used in preclinical studies to understand mechanisms of retinoid action in various cancer models.

Cell Biology and Signalling

This compound serves as a valuable tool in cell biology research for studying retinoid signalling pathways. It is used to investigate its effects on gene expression and cellular processes regulated by nuclear receptors.

Biochemical Research

As a bioactive small molecule, 9-cis-Retinoic acid is employed in biochemical assays to explore its interactions with proteins and its metabolic pathways. Its defined purity makes it suitable for quantitative studies.

Gene Regulation Studies

The molecule is used to study the regulation of gene expression, particularly its interaction with Retinoic Acid Receptors (RARs) and Retinoid X Receptors (RXRs). This is critical for understanding developmental biology and disease processes.

02 /Properties

Molecular weight	300.44
Empirical formula	C20H28O2
Assay	≥98% (HPLC)
Storage temperature	−20°C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use
P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES
P308IF exposed or concerned

Protective equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	61-36/37/38
Safety statements (S)	53-26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

5300-03-8

MDL number

MFCD00270072

PubChem substance

24899373

05 /Additional specifications

Gene Information	human ... RARA(5914), RARB(5915), RARG(5916), RXRA(6256), RXRB(6257), RXRG(6258)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is 9-cis-Retinoic acid used for?

9-cis-Retinoic acid is primarily used in scientific research, including cancer research, cell biology, and studies on gene regulation and signalling pathways, due to its role as a Vitamin A derivative and its effects on cell differentiation and apoptosis.

What are the CAS number and formula for 9-cis-Retinoic acid?

The CAS number for 9-cis-Retinoic acid is 5300-03-8, and its molecular formula is C20H28O2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 9-cis-Retinoic acid with a purity of ≥98% (HPLC). This product is intended for research purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.

How should 9-cis-Retinoic acid be handled safely?

9-cis-Retinoic acid presents significant hazards, including potential reproductive toxicity and irritation. It requires careful handling with appropriate personal protective equipment, such as gloves, eyecups, and respiratory protection (e.g., N100 or P3 filters). Always consult the Safety Data Sheet (SDS) before use.

Is 9-cis-Retinoic acid a controlled substance?

While not explicitly listed as a controlled substance in common drug control schedules, its classification as potentially teratogenic (H360) necessitates careful handling and adherence to all safety regulations.

How is 9-cis-Retinoic acid packed and shipped?

9-cis-Retinoic acid is typically stored at -20°C. TSS ensures that all products are packed and shipped in compliance with relevant regulations for chemical substances.

How can I request a sample or quote for 9-cis-Retinoic acid?

To request a sample or a quote for 9-cis-Retinoic acid, please contact our sales team through the TSS website or by phone, providing your specific requirements and shipping details.