6-Hydroxyindole
6-Hydroxyindole (CAS 2380-86-1), with the molecular formula C8H7NO and a molecular weight of 133.15, is a valuable heterocyclic building block. It serves as a crucial reactant in the synthesis of diverse biologically active compounds. Its applications span the development of potential anticancer immunomodulators, antituberculosis agents, and compounds investigated for HIV inhibition and as peroxisome proliferator-activated receptor agonists. This indole derivative is essential for advanced chemical synthesis.
- IUPAC
- 6-Indolol
Anticancer and Immunomodulatory Agent Synthesis
6-Hydroxyindole is utilised as a key reactant in the preparation of pyridyl-ethenyl-indoles. These compounds are investigated for their potential as anticancer immunomodulators, targeting mechanisms related to tryptophan dioxygenase inhibition.
Biosynthetic Precursor Analogues
This compound serves as a reactant in the asymmetrical synthesis of notoamide J analogues. This contributes to the study of prenylated indole alkaloids and their potential biosynthetic pathways.
Antituberculosis Agent Development
It is employed in the synthesis of (quinolinyloxymethyl)isoxazolecarboxylate esters, a class of compounds being developed as potential agents against tuberculosis.
Antiviral Compound Synthesis
6-Hydroxyindole is a reactant in the preparation of indolyl(propanolamine) derivatives. These molecules are explored for their inhibitory activity against HIV.
Peroxisome Proliferator-Activated Receptor (PPAR) Agonists
The compound is used in the synthesis of indoleoxyacetic acid derivatives, which are investigated as agonists for peroxisome proliferator-activated receptors.
Antitumor Agent and Tubulin Polymerization Inhibitor Research
It acts as a reactant for preparing 1-aroylindole 3-aroylindoles, specifically combretastatin A-4 analogues. These are studied for their antitumor properties and ability to inhibit tubulin polymerisation.
| Molecular weight | 133.15 |
|---|---|
| Empirical formula | C8H7NO |
| Assay | ≥99.0% (GC) |
| Application | • Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators1• Reactant for asymmetrical synthesis of notoamide J as a potential biosynthetic precursor of prenylated indole alkaloids2• Reactant for preparation of (quinolinyloxymethyl)isoxazolecarboxylate esters antituberculosis agents3• Reactant for preparation of indolyl(propanolamine) derivatives as HIV inhibitors4• Reactant for preparation of indoleoxyacetic acid derivatives as peroxisome proliferator-activated receptor agonists5• Reactant for preparation of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors6 |
| Melting point | 125-128 °C |
Hazard statements
- H302Harmful if swallowed
- H317May cause an allergic skin reaction
- H318Causes serious eye damage
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-41-43-51/53 |
| Safety statements (S) | 24-26-37/39-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Hydroxyindole used for?
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6-Hydroxyindole is used as a reactant in the synthesis of various biologically active compounds, including potential anticancer immunomodulators, antituberculosis agents, HIV inhibitors, and PPAR agonists.
What are the CAS number and formula for 6-Hydroxyindole?
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The CAS number for 6-Hydroxyindole is 2380-86-1, and its molecular formula is C8H7NO.
What grade and purity does Tech Serve Solutions supply for 6-Hydroxyindole?
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Tech Serve Solutions supplies 6-Hydroxyindole with a purity of ≥99.0% (GC). TSS does not represent this product as USP, BP, or EP grade.
How should 6-Hydroxyindole be handled safely?
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6-Hydroxyindole is classified as hazardous (H302, H317, H318, H411). Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, faceshields, and gloves. Avoid contact with skin and eyes, and ensure good ventilation. Refer to the safety data sheet for detailed handling instructions.
Is 6-Hydroxyindole a controlled substance?
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The provided data does not indicate that 6-Hydroxyindole is a controlled substance.
How is 6-Hydroxyindole packed and shipped?
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6-Hydroxyindole is shipped as a hazardous material (UN 3077, Class 9, Packing Group III). Packaging details are available upon request, and TSS exports globally.
How can I request a sample or quote for 6-Hydroxyindole?
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To request a sample or a quote for 6-Hydroxyindole, please contact the TSS sales team via our website or direct contact details.
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