5-Methoxygramine
5-Methoxygramine (CAS: 16620-52-3), with the molecular formula C12H16N2O and a molecular weight of 204.27 g/mol, is a heterocyclic organic compound. It serves as a key reactant in various synthetic pathways. Its primary applications include the preparation of dopamine receptor ligands and antitubulin agents. This compound is a valuable building block for complex molecule synthesis in research and development settings.
- IUPAC
- 3-(Dimethylaminomethyl)-5-methoxyindole,NSC 88885
- Synonyms
- 3-(Dimethylaminomethyl)-5-methoxyindole,NSC 88885
Dopamine Receptor Antagonist Synthesis
5-Methoxygramine is utilised as a reactant in the preparation of dopamine D2 receptor antagonists, contributing to the development of neurological research compounds.
Carbazole Derivative Preparation
It serves as a reactant in the asymmetric synthesis of ethenyl(tetrahydro)carbazoledicarboxylates through gold(I)-catalyzed intramolecular Friedel-Crafts allylic alkylation reactions.
Dopamine D2-like Receptor Ligand Development
The compound is employed in the synthesis of N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ols, which act as ligands for dopamine D2-like receptors.
Antitubulin Agent Synthesis
5-Methoxygramine is a reactant for preparing substituted N-trimethoxybenzoyl indoles, indolines, and tetrahydroquinolines that exhibit antitubulin activity.
Indolylmethanesulfonamide Derivatives
It is used as a reactant in the synthesis of indolylmethanesulfonamide and its related methoxy derivatives.
| Molecular weight | 204.27 |
|---|---|
| Empirical formula | C12H16N2O |
| Assay | 99% |
| Application | • Reactant for preparation of dopamine D2 receptor antagonists1• Reactant for asymmetric preparation of ethenyl(tetrahydro)carbazoledicarboxylates via gold(I)-catalyzed intramolecular Friedel-Crafts allylic alkylation reaction2• Reactant for preparation of N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ols as dopamine D2-like receptor ligands3• Reactant for preparation of substituted N-trimethoxybenzoyl indoles, indolines, and a tetrahydroquinoline via N-aroylation with trimethoxybenzoyl chloride or anhydride as antitubulin agents4• Reactant for preparation of indolylmethanesulfonamide and its methoxy derivatives5 |
| Melting point | 123-126 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Methoxygramine used for?
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5-Methoxygramine is used as a reactant in the synthesis of various pharmaceutical intermediates, including dopamine receptor antagonists, antitubulin agents, and other complex heterocyclic compounds.
What are the CAS number and formula for 5-Methoxygramine?
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The CAS number for 5-Methoxygramine is 16620-52-3, and its molecular formula is C12H16N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Methoxygramine with an assay of 99%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.
How should 5-Methoxygramine be handled safely?
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When handling 5-Methoxygramine, it is essential to use personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used when exposure is possible. Consult the Safety Data Sheet for comprehensive handling guidelines.
Is 5-Methoxygramine a controlled substance?
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Based on the provided data, there is no indication that 5-Methoxygramine is a controlled substance.
How is 5-Methoxygramine typically packed and shipped?
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5-Methoxygramine is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions in compliance with all relevant shipping regulations.
How can I request a quote or sample for 5-Methoxygramine?
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To request a quote or a sample of 5-Methoxygramine, please contact our sales team through the website or by calling our customer service number.
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