5-Hydroxyindole
5-Hydroxyindole (CAS: 1953-54-4, C8H7NO) is a key indole derivative supplied by Tech Serve Solutions. With a molecular weight of 133.15 g/mol, this compound serves as a versatile building block in organic synthesis. Its primary applications lie in the development of pharmaceutical intermediates, including potential antitumor agents, dopamine receptor antagonists, and radioprotectors.
- IUPAC
- 5-Hydroxyindole,5-Indolol,NSC 87503
- Synonyms
- 5-IndololNSC 87503
Antitumor Agents and Tubulin Inhibitors
5-Hydroxyindole is utilised as a reactant in the synthesis of (oxoimidazolidinyl/oxopyrimidinyl)benzenesulfonates, which have demonstrated potential as antitumor agents and tubulin inhibitors.
Anthranilic Acid Synthesis
This compound serves as a precursor in the preparation of various anthranilic acid derivatives, contributing to diverse synthetic pathways in medicinal chemistry.
Dopamine Receptor Antagonists
It is employed in the synthesis of novel indole compounds designed to act as antagonists for dopamine D2 receptors, relevant in neurological research.
Radioprotective Melanin Analogues
5-Hydroxyindole is a reactant in the creation of melanins, which are explored for their properties as nature-inspired radioprotectors.
PKCθ Inhibitor Precursors
The compound is used in the preparation of 5-vinyl-3-pyridinecarbonitriles, investigated as inhibitors of protein kinase C theta (PKCθ).
| Molecular weight | 133.15 |
|---|---|
| Empirical formula | C8H7NO |
| Assay | 97% |
| Application | • Reactant for preparation of (oxoimidazolidinyl/oxopyrimidinyl)benzenesulfonates as antitumor agents and tubulin inhibitors1• Reactant for preparation of anthranilic acids2• Reactant for preparation of indole compounds as dopamine D2 receptor antagonists3• Reactant for preparation of naphthalimide- or carbazole-containing human β-adrenoceptor ligands4• Reactant for preparation of melanins as nature-inspired radioprotectors5• Reactant for preparation of 5-vinyl-3-pyridinecarbonitriles as PKCθ inhibitors6 |
| Melting point | 106-108 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Hydroxyindole used for?
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5-Hydroxyindole is primarily used as a reactant in organic synthesis for the preparation of various compounds including potential antitumor agents, dopamine receptor antagonists, radioprotectors, and enzyme inhibitors.
What are the CAS number and molecular formula for 5-Hydroxyindole?
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The CAS number for 5-Hydroxyindole is 1953-54-4, and its molecular formula is C8H7NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Hydroxyindole with a minimum purity of 97%. TSS does not represent this product as USP, BP, or EP grade.
How should 5-Hydroxyindole be handled safely?
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5-Hydroxyindole is classified as a warning substance. It can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is 5-Hydroxyindole packed, shipped, and exported?
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5-Hydroxyindole is typically packed in appropriate containers to ensure stability and safety during transit. TSS can facilitate global export of this chemical.
How can I request a sample or quote for 5-Hydroxyindole?
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To request a sample or a quote for 5-Hydroxyindole, please contact the TSS sales department through our website or by phone.
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