5-Hydroxyindole-2-carboxylic acid
5-Hydroxyindole-2-carboxylic acid (CAS: 21598-06-1, C9H7NO3) is a valuable heterocyclic building block. With a molecular weight of 177.16 g/mol, this indole derivative serves as a key reactant in the synthesis of complex organic molecules. Its applications span the development of potential anticancer agents, ligands for serotonin receptors, novel radioprotectors, and inhibitors targeting various biological pathways. TSS supplies this compound for research and chemical synthesis purposes.
- IUPAC
- NSC 117338
Anticancer Agent Precursors
Serves as a reactant in the preparation of indole C5-O-substituted seco-cyclopropylindole analogs investigated for their potential anticancer properties.
Serotonin Receptor Ligand Synthesis
Used as a reactant in microwave combinatorial synthesis to create indolic arylpiperazine derivatives, which act as ligands for 5-HT1A, 5-HT2A, and 5-HT2C receptors.
Radioprotector Development
Functions as a reactant in the preparation of melanins, exploring their utility as novel, nature-inspired radioprotective agents.
Obesity Treatment Research
A reactant in the synthesis of 5-Hydroxyindole-2-carboxylic acid amides, which are being explored as histamine-3 receptor inverse agonists for obesity treatment.
Signal Transducer Inhibitor Synthesis
Employed as a reactant for creating conformationally constrained peptidomimetic inhibitors targeting the signal transducer and activator of transcription 3 (Stat3).
| Molecular weight | 177.16 |
|---|---|
| Empirical formula | C9H7NO3 |
| Assay | 98% |
| Solubility | chloroform/ethanol (1:1): soluble50 mg/mL, clear to slightly hazy, yellow to brown |
| Application | • Reactant for preparation of indole C5-O-substituted seco-cyclopropylindole analogs as potential anticancer agents• Reactant for microwave combinatorial synthesis of indolic arylpiperazine derivatives as ligands for 5-HT1A, 5-HT2A, and 5-HT2C receptors1• Reactant for preparation of melanins as novel nature-inspired radioprotectors2• Reactant for preparation of 5-Hydroxyindole-2-carboxylic acid amides as histamine-3 receptor inverse agonists for the treatment of obesity3• Reactant for preparation of conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription 3 (Stat3)4• Reactant for preparation of oxadiazole analogs as nonpeptidic SH2 inhibitors of tyrosine kinase ZAP-705 |
| Melting point | 249 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Hydroxyindole-2-carboxylic acid used for?
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5-Hydroxyindole-2-carboxylic acid is primarily used as a reactant and building block in chemical synthesis for developing potential anticancer agents, ligands for serotonin receptors, radioprotectors, and inhibitors for various biological targets.
What are the CAS number and formula for 5-Hydroxyindole-2-carboxylic acid?
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The CAS number is 21598-06-1, and the empirical formula is C9H7NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Hydroxyindole-2-carboxylic acid with an assay of 98%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated otherwise in the product documentation.
How should 5-Hydroxyindole-2-carboxylic acid be handled?
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Handle with appropriate personal protective equipment, including a dust mask (N95 type recommended), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. Refer to the Safety Data Sheet for comprehensive handling information. Hazards include skin irritation (H315), eye irritation (H319), and respiratory irritation (H335).
Is 5-Hydroxyindole-2-carboxylic acid a controlled substance?
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Based on the provided data, there is no indication that 5-Hydroxyindole-2-carboxylic acid is a controlled substance.
How is 5-Hydroxyindole-2-carboxylic acid packed and shipped?
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The product is typically packed in quantities suitable for laboratory and research use. TSS exports chemicals globally, adhering to all relevant shipping and customs regulations.
How can I request a sample or quote for 5-Hydroxyindole-2-carboxylic acid?
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To request a sample or a quote, please use the contact form on our website or email our sales department, providing the product name and CAS number (21598-06-1).
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