5-Fluoroindole
5-Fluoroindole (CAS: 399-52-0), with the molecular formula C8H6FN and a molecular weight of 135.14 g/mol, is a valuable heterocyclic building block. This fluorinated indole derivative serves as a key reactant in the synthesis of various biologically active compounds. Its applications span the development of potential therapeutic agents, including receptor ligands, anticancer immunomodulators, and agents for managing diabetes.
- IUPAC
- NSC 88613
Preparation of 5-HT6 Receptor Ligands
5-Fluoroindole is utilised as a reactant in the synthesis of compounds targeting the 5-HT6 receptor. This research is relevant for potential neurological and psychiatric therapeutic development.
Synthesis of Tryptophan Dioxygenase Inhibitors
This compound serves as a precursor for preparing pyridyl-ethenyl-indoles, which act as inhibitors of tryptophan dioxygenase. These inhibitors are investigated for their potential as anticancer immunomodulators.
Development of Antitumor and Antibacterial Agents
5-Fluoroindole is employed in synthetic pathways leading to novel antitumor and antibacterial agents. Its structural features are leveraged to create molecules with potential therapeutic efficacy against various diseases.
Preparation of SGLT2 Inhibitors
The compound is a reactant in the synthesis of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) inhibitors. These are developed for managing hyperglycemia in patients with diabetes.
| Molecular weight | 135.14 |
|---|---|
| Empirical formula | C8H6FN |
| Assay | 98% |
| Application | • Reactant for preparation of 5-HT6 receptor ligands1• Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators2• Reactant for preparation of antitumor agents3• Reactant for preparation of antibacterial agents4• Reactant for preparation of immunosuppressive agents5• Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes6• Reactant for preparation of Myeloperoxidase Inhibitors7• Reactant for preparation of Potent Selective Serotonin Reuptake Inhibitors8 |
| Melting point | 45-48 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoroindole used for?
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5-Fluoroindole is primarily used as a reactant in chemical synthesis for the preparation of various biologically active compounds, including potential therapeutic agents like receptor ligands, anticancer immunomodulators, antitumor agents, antibacterial agents, immunosuppressive agents, SGLT2 inhibitors, and serotonin reuptake inhibitors.
What are the CAS number and molecular formula of 5-Fluoroindole?
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The CAS number for 5-Fluoroindole is 399-52-0, and its molecular formula is C8H6FN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Fluoroindole with a purity of 98%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling requirements for 5-Fluoroindole?
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5-Fluoroindole is classified as a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Recommended personal protective equipment includes a dust mask type N95, eyeshields, and gloves. Handle in a well-ventilated area and avoid breathing dust. Store in a tightly closed container.
How is 5-Fluoroindole packed and shipped?
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5-Fluoroindole is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions. Specific packaging details are available upon request.
How can I request a sample or quote for 5-Fluoroindole?
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To request a sample or a quotation for 5-Fluoroindole, please contact our sales department through our website or by phone.
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