5-Fluoroindole-2-carboxylic acid
5-Fluoroindole-2-carboxylic acid (CAS: 399-76-8) is a fluorinated heterocyclic building block with the molecular formula C9H6FNO2 and a molecular weight of 179.15. This compound serves as a crucial intermediate in the synthesis of various biologically active molecules. Its applications span the development of fungicidal and antibacterial agents, antitumor compounds, and inhibitors for enzymes and receptors involved in inflammation and viral replication.
Synthesis of Fungicidal and Antibacterial Agents
5-Fluoroindole-2-carboxylic acid is a key reactant in the preparation of novel compounds exhibiting fungicidal and antibacterial properties, contributing to the development of new antimicrobial therapies.
Development of Antitumor Agents
This fluorinated indole derivative is employed in the synthesis of potential antitumor agents, acting as a valuable building block in oncology research and drug discovery.
Preparation of Enzyme and Receptor Inhibitors
It is utilised in the synthesis of inhibitors for various biological targets, including 2,3-dioxygenase (IDO), Factor Xa, and ligands for the hFPRL1 receptor, relevant to inflammatory diseases and thrombosis.
Intermediate for Antiviral Compounds
The compound serves as a precursor in the development of inhibitors for viral proteases, such as the hepatitis C virus NS3·4A protease, aiding in the search for antiviral treatments.
| Molecular weight | 179.15 |
|---|---|
| Empirical formula | C9H6FNO2 |
| Assay | 99% |
| Application | Reactant for the synthesis of:• Fungicidal agents1• Antitumor agents2• 2,3-dioxygenase (IDO) inhibitors3• Factor Xa inhibitors4• Enantioselective D3 receptor antagonists5• Ligands for hFPRL1 (or ALXR) receptor in inflammation6• Antibacterial agents7• Inhibitors of hepatitis C virus NS3·4A protease8 |
| Melting point | 259 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoroindole-2-carboxylic acid used for?
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5-Fluoroindole-2-carboxylic acid is used as a building block and reactant in chemical synthesis, primarily for the preparation of fungicidal agents, antitumor agents, enzyme inhibitors (such as IDO and Factor Xa inhibitors), and antiviral compounds.
What is the CAS number and chemical formula for 5-Fluoroindole-2-carboxylic acid?
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The CAS number is 399-76-8 and the chemical formula is C9H6FNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Fluoroindole-2-carboxylic acid with an assay of 99%. This product is suitable for research and chemical synthesis purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 5-Fluoroindole-2-carboxylic acid be handled safely?
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5-Fluoroindole-2-carboxylic acid is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, in a well-ventilated area.
Is 5-Fluoroindole-2-carboxylic acid a controlled substance?
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The provided data does not indicate that 5-Fluoroindole-2-carboxylic acid is a controlled substance.
How is 5-Fluoroindole-2-carboxylic acid packed, shipped, and exported?
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5-Fluoroindole-2-carboxylic acid is carefully packed to ensure safe transit. As a global supplier and exporter, Tech Serve Solutions adheres to all relevant shipping and export regulations for chemical compounds.
How can I request a sample or quote for 5-Fluoroindole-2-carboxylic acid?
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To request a sample or a quotation for 5-Fluoroindole-2-carboxylic acid, please contact the Tech Serve Solutions sales team via our website or direct inquiry channels.
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