5-Fluoro-L-tryptophan
5-Fluoro-L-tryptophan (CAS: 16626-02-1; Formula: C11H11FN2O2; MW: 222.22) is a fluorinated amino acid analogue. It is primarily utilised in biochemical research as an exogenous building block for protein synthesis, allowing for the incorporation of a 19F reporter group. This facilitates the study of enzyme mechanisms and protein structures using NMR spectroscopy. It is also employed as a substrate analog in enzyme inhibition studies.
Biochemical Research
5-Fluoro-L-tryptophan serves as an exogenous amino acid analogue for incorporation into proteins during normal protein synthesis. The presence of the fluorine atom allows for 19F NMR studies, aiding in the investigation of enzyme mechanisms and protein structural dynamics.
Enzyme Mechanism Studies
Utilising 5-Fluoro-L-tryptophan in protein synthesis provides a non-invasive method to introduce a 19F nucleus. This enables detailed studies of enzyme active sites and reaction pathways through Nuclear Magnetic Resonance (NMR) spectroscopy, offering insights into catalytic processes.
Substrate Analog
As a derivative of L-tryptophan, this compound can act as a substrate analog in enzymatic reactions. This property is valuable for studying enzyme kinetics and developing enzyme inhibitors by competing with the natural substrate.
| Molecular weight | 222.22 |
|---|---|
| Empirical formula | C11H11FN2O2 |
| Assay | ≥98.0% (HPLC) |
| Optical purity | enantiomeric ratio: ≥99.5:0.5 (HPLC) |
| Storage temperature | 2-8°C |
| Application | Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis3. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR4. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoro-L-tryptophan used for?
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5-Fluoro-L-tryptophan is primarily used in biochemical research as an exogenous amino acid analogue for protein synthesis. Its 19F label is useful for studying enzyme mechanisms and protein structures via NMR spectroscopy, and it can also function as a substrate analog.
What are the CAS number and chemical formula for 5-Fluoro-L-tryptophan?
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The CAS number for 5-Fluoro-L-tryptophan is 16626-02-1, and its chemical formula is C11H11FN2O2.
What grade and purity does Tech Serve Solutions supply for 5-Fluoro-L-tryptophan?
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Tech Serve Solutions supplies 5-Fluoro-L-tryptophan with an assay of ≥98.0% (HPLC) and enantiomeric purity of ≥99.5:0.5 (HPLC). We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.
What are the safety and handling recommendations for 5-Fluoro-L-tryptophan?
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Handling 5-Fluoro-L-tryptophan requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK Germany 3.
How is 5-Fluoro-L-tryptophan packed, shipped, and exported?
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5-Fluoro-L-tryptophan is stored at 2-8°C. Tech Serve Solutions, as a specialist global supplier and exporter of fine chemicals, handles the packing, shipping, and export of this product in compliance with all relevant regulations.
How can I request a quote or sample for 5-Fluoro-L-tryptophan?
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To request a quote or a sample of 5-Fluoro-L-tryptophan, please contact our sales team directly via our website or by phone. Our representatives will be pleased to assist you with your inquiry.
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