5-Azacytidine
5-Azacytidine (CAS 320-67-2, C8H12N4O5, MW 244.20) is a pyrimidine analogue with significant biological activity. Primarily recognised for its role as an antineoplastic and immunosuppressive agent, it functions as a DNA methyltransferase inhibitor. This compound is crucial in epigenetic research and is utilised in various research applications targeting cellular differentiation and gene expression.
- IUPAC
- 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one,Ladakamycin
- Synonyms
- Ladakamycin
Epigenetic Research
5-Azacytidine is a key tool for investigating DNA methylation and its role in gene regulation. It is widely used in studies to understand how epigenetic modifications influence cellular processes, including development and disease.
Antineoplastic Agent Research
As a DNA methyltransferase inhibitor, 5-Azacytidine is researched for its potential in cancer therapy. It has been studied for its ability to induce differentiation and inhibit the growth of tumour cells.
Immunosuppressive Studies
The compound's ability to modulate immune responses makes it a subject of interest in research related to autoimmune diseases and transplantation.
Cell Biology Reagent
5-Azacytidine serves as a valuable reagent in cell biology laboratories for studies involving cellular differentiation, gene silencing, and other epigenetic phenomena.
| Molecular weight | 244.20 |
|---|---|
| Empirical formula | C8H12N4O5 |
| Assay | ≥98% (HPLC) |
| Storage temperature | −20°C |
| Impurities tested | endotoxin, tested |
| Suitability | suitable for hybridoma |
| Melting point | 226-232 °C (dec.)(lit.) |
Hazard statements
- H302Harmful if swallowed
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P308IF exposed or concerned
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-46-22 |
| Safety statements (S) | 22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... DNMT1(1786), DNMT3A(1788), DNMT3B(1789) |
|---|---|
| Sterility | γ-irradiated |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Azacytidine used for?
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5-Azacytidine is primarily used in research for its antineoplastic, immunosuppressive, and epigenetic modifying properties, particularly as a DNA methyltransferase inhibitor.
What are the CAS number and formula for 5-Azacytidine?
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The CAS number for 5-Azacytidine is 320-67-2, and its molecular formula is C8H12N4O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Azacytidine with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should 5-Azacytidine be handled safely?
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Due to its hazardous nature (H302-H350), handle 5-Azacytidine with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Consult the Safety Data Sheet for detailed handling instructions.
How is 5-Azacytidine shipped?
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This product is supplied sterile, γ-irradiated, and should be stored at -20°C. Tech Serve Solutions exports fine chemicals globally.
How can I request a sample or quote for 5-Azacytidine?
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To request a sample or obtain a quote for 5-Azacytidine, please contact our sales team through the website or via email.
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