4-(Trifluoromethyl)pyrimidine-2-thiol
4-(Trifluoromethyl)pyrimidine-2-thiol (CAS: 136547-17-6; C5H3F3N2S) is a heterocyclic organic compound with a molecular weight of 180.15 g/mol. It functions as a key building block in chemical synthesis, particularly within the realm of heterocyclic chemistry. Its structure, featuring a trifluoromethyl group and a thiol on a pyrimidine ring, makes it valuable for introducing specific functionalities into more complex molecules, especially in the development of novel pharmaceutical intermediates and agrochemicals.
Organic Synthesis Intermediate
This compound serves as a versatile building block in organic synthesis, enabling the construction of more complex heterocyclic structures. Its reactive thiol group and substituted pyrimidine core are amenable to various chemical transformations.
Pharmaceutical Research and Development
Utilised in medicinal chemistry for the synthesis of potential drug candidates. The pyrimidine moiety is a common scaffold in biologically active molecules, and the trifluoromethyl group can modulate pharmacokinetic properties.
Agrochemical Discovery
Can be incorporated into the synthesis of novel agrochemical compounds. Heterocyclic structures are frequently found in pesticides, herbicides, and fungicides due to their diverse biological activities.
| Molecular weight | 180.15 |
|---|---|
| Empirical formula | C5H3F3N2S |
| Assay | 96% |
| Melting point | 164-166 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethyl)pyrimidine-2-thiol used for?
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4-(Trifluoromethyl)pyrimidine-2-thiol is primarily used as a building block in organic synthesis, particularly for developing new pharmaceutical intermediates and agrochemicals due to its heterocyclic structure and trifluoromethyl substituent.
What are the CAS number and formula for 4-(Trifluoromethyl)pyrimidine-2-thiol?
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The CAS number is 136547-17-6, and the empirical formula is C5H3F3N2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Trifluoromethyl)pyrimidine-2-thiol with a minimum assay of 96%. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 4-(Trifluoromethyl)pyrimidine-2-thiol be handled safely?
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This compound is classified as Danger (GHS06) with hazard statements H301-H311-H331, indicating it is toxic if swallowed, in contact with skin, or if inhaled. Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and P2 respirator cartridges, must be used. Handle only in well-ventilated areas and avoid exposure. Refer to the Safety Data Sheet (SDS) for comprehensive handling instructions.
How is 4-(Trifluoromethyl)pyrimidine-2-thiol shipped and exported?
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Tech Serve Solutions exports and ships 4-(Trifluoromethyl)pyrimidine-2-thiol globally, adhering to all relevant transportation regulations for hazardous materials (UN 2811, 6.1, PGIII).
How can I request a quote or sample for 4-(Trifluoromethyl)pyrimidine-2-thiol?
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To request a quote or a sample, please use the contact form on our website or reach out to our sales department directly with your specific requirements.
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