4-(Trifluoromethylsulfonyl)aniline
4-(Trifluoromethylsulfonyl)aniline (CAS: 473-27-8) is an organic compound with the formula CF3SO2C6H4NH2. This trifluoromethylated aniline derivative serves as a valuable building block in chemical synthesis. Its structure, featuring both a trifluoromethylsulfonyl group and an amine functionality, makes it useful for introducing specific chemical properties into more complex molecules, particularly in the fields of organic chemistry and materials science.

Organic Synthesis Intermediate
This compound is primarily used as an intermediate in the synthesis of complex organic molecules. The presence of the electron-withdrawing trifluoromethylsulfonyl group can influence the reactivity of the aniline moiety, enabling selective transformations.
Pharmaceutical Research
As a building block, 4-(Trifluoromethylsulfonyl)aniline can be employed in the research and development of novel pharmaceutical agents. Its structural features may contribute to the biological activity or pharmacokinetic properties of candidate drugs.
Materials Science
The unique electronic properties conferred by the trifluoromethylsulfonyl group make this aniline derivative a potential component in the development of advanced materials, such as specialised polymers or dyes.
| Molecular weight | 225.19 |
|---|---|
| Linear formula | CF3SO2C6H4NH2 |
| Assay | 95% |
| Melting point | 96 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethylsulfonyl)aniline used for?
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4-(Trifluoromethylsulfonyl)aniline is primarily used as a building block and intermediate in organic synthesis, with applications in pharmaceutical research and materials science.
What are the CAS number and formula for 4-(Trifluoromethylsulfonyl)aniline?
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The CAS number is 473-27-8 and the chemical formula is CF3SO2C6H4NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Trifluoromethylsulfonyl)aniline with an assay of 95%. We do not represent this product as USP, BP, or EP grade.
How should 4-(Trifluoromethylsulfonyl)aniline be handled?
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Handling requires appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid inhalation of dust, skin contact, and eye contact, as it may cause respiratory irritation, skin irritation, and serious eye irritation.
How is 4-(Trifluoromethylsulfonyl)aniline packed, shipped, and exported?
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Tech Serve Solutions expertly packs, ships, and exports chemicals globally, adhering to all relevant safety and regulatory standards for international transit.
How can I request a sample or quote for 4-(Trifluoromethylsulfonyl)aniline?
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To request a sample or quote, please use the contact form on our website or reach out to our sales department directly.
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