4-(Trifluoromethyl)piperidine hydrochloride
4-(Trifluoromethyl)piperidine hydrochloride (CAS: 155849-49-3) is a chemical compound with the molecular formula C6H10F3N · HCl. This fluorinated piperidine derivative serves as a valuable building block in organic synthesis. It is particularly useful in C,N-cross coupling reactions and plays a role in the synthesis of specific pharmaceutical intermediates, such as dopamine D3 receptor antagonists. Its structural features make it a versatile reagent for introducing the trifluoromethylpiperidine moiety into more complex molecules.
C,N-Cross Coupling Reactions
This compound acts as a reactant in C,N-cross coupling reactions, facilitating the formation of new carbon-nitrogen bonds. This is a key transformation in the synthesis of many organic molecules, including pharmaceuticals and agrochemicals.
Synthesis of Dopamine D3 Receptor Antagonists
4-(Trifluoromethyl)piperidine hydrochloride is utilised in the synthetic pathways leading to dopamine D3 receptor antagonists. These compounds are of interest in pharmacological research for potential therapeutic applications.
Heterocyclic Building Block
As a substituted piperidine, this chemical serves as a versatile heterocyclic building block. It allows for the incorporation of a trifluoromethyl group onto a piperidine ring, enabling access to a range of novel chemical entities.
| Molecular weight | 189.61 |
|---|---|
| Empirical formula | C6H10F3N · HCl |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Application | Reactnat for:• C,N-cross coupling reactions1• Synthesis of dopamine D3 receptor antagonists2 |
| Melting point | 155-159 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethyl)piperidine hydrochloride used for?
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4-(Trifluoromethyl)piperidine hydrochloride is used as a reactant in C,N-cross coupling reactions and in the synthesis of dopamine D3 receptor antagonists. It is a valuable building block for chemical synthesis, particularly for introducing trifluoromethylpiperidine moieties.
What are the CAS number and molecular formula?
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The CAS number for 4-(Trifluoromethyl)piperidine hydrochloride is 155849-49-3, and its molecular formula is C6H10F3N · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Trifluoromethyl)piperidine hydrochloride with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the primary safety considerations when handling this chemical?
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This compound is classified with GHS07 symbol and a 'Warning' signal word. It carries hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment including a dust mask (type N95 US), eyeshields, and gloves should be worn. Handle in a well-ventilated area.
How is 4-(Trifluoromethyl)piperidine hydrochloride shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. 4-(Trifluoromethyl)piperidine hydrochloride is carefully packed and handled in accordance with international shipping regulations for chemical export.
How can I request a sample or quote for this product?
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To request a sample or a quotation for 4-(Trifluoromethyl)piperidine hydrochloride, please contact our sales team through the website or by phone. Our experts will be pleased to assist you.
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