4-(Trifluoromethyl)phenylboronic acid
4-(Trifluoromethyl)phenylboronic acid (CAS: 128796-39-4, Formula: CF3C6H4B(OH)2, MW: 189.93) is a key organometallic reagent supplied by Tech Serve Solutions. This aryl boronic acid derivative is essential for various cross-coupling reactions, including Suzuki-Miyaura, palladium-catalyzed direct arylation, and rhodium-catalyzed asymmetric additions. Its utility spans organic synthesis, particularly in preparing complex molecules and intermediates for advanced chemical and pharmaceutical research.
- IUPAC
- α,α,α-Trifluoro-p-tolylboronic acid,4-(Trifluoromethyl)benzeneboronic acid,[p-(Trifluoromethyl)phenyl]boronic acid
- Synonyms
- α,α,α-Trifluoro-p-tolylboronic acid4-(Trifluoromethyl)benzeneboronic acid[p-(Trifluoromethyl)phenyl]boronic acid
Suzuki-Miyaura Cross-Coupling Reactions
Utilised in site-selective and regioselective Suzuki-Miyaura cross-coupling reactions, a fundamental method for carbon-carbon bond formation. It is also employed in tandem palladium-catalyzed intramolecular aminocarbonylation and annulation sequences.
Palladium-Catalyzed Arylation and Heck Reactions
Serves as a crucial reagent in palladium-catalyzed direct arylation reactions and in tandem-type oxidative Heck reactions coupled with intramolecular C-H amidation sequences.
Ruthenium and Rhodium Catalysis
Applicable in ruthenium-catalyzed direct arylation and rhodium-catalyzed asymmetric 1,4-addition reactions, expanding its scope in stereoselective synthesis.
Copper-Catalyzed Transformations
Engaged in ligand-free copper-catalyzed coupling reactions, amination, conjugate addition reactions, and copper-catalyzed nitration reactions.
| Molecular weight | 189.93 |
|---|---|
| Linear formula | CF3C6H4B(OH)2 |
| Assay | ≥95.0% |
| Application | Reagent used for• Site-selective Suzuki-Miyaura cross-coupling reactions1• Palladium-catalyzed direct arylation reactions2• Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence3• Ruthenium catalyzed direct arylation4• Ligand-free copper-catalyzed coupling reactions5• Amination and conjugate addition reactions6• Regioselective arylation and alkynylation by Suzuki-Miyaura and Sonogashira cross-coupling reactions7• Rhodium-catalyzed asymmetric 1,4-addition reactions8• Copper-catalyzed nitration reactions9• Regioselective Suzuki-Miyaura coupling and tandem palladium-catalyzed intramolecular aminocarbonylation and annulation10Reagent used in Preparation of• Thiazole deriv |
| Melting point | 245-250 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethyl)phenylboronic acid used for?
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4-(Trifluoromethyl)phenylboronic acid is a versatile reagent primarily used in various cross-coupling reactions such as Suzuki-Miyaura, palladium-catalyzed direct arylation, and Heck reactions. It also finds application in ruthenium and rhodium-catalyzed transformations, as well as copper-catalyzed coupling and nitration reactions.
What are the CAS number and formula for 4-(Trifluoromethyl)phenylboronic acid?
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The CAS number for 4-(Trifluoromethyl)phenylboronic acid is 128796-39-4, and its linear formula is CF3C6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Trifluoromethyl)phenylboronic acid with a minimum assay of ≥95.0%. This product is intended for laboratory and research use, and TSS does not represent it as USP, BP, or EP grade.
How should 4-(Trifluoromethyl)phenylboronic acid be handled safely?
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4-(Trifluoromethyl)phenylboronic acid is classified with GHS07 symbol and a 'Warning' signal word, presenting H302 hazard statement. Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, in a well-ventilated area.
Is 4-(Trifluoromethyl)phenylboronic acid available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-(Trifluoromethyl)phenylboronic acid, and can fulfil international orders.
How can I request a quote or sample?
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To request a quote or a sample of 4-(Trifluoromethyl)phenylboronic acid, please contact the Tech Serve Solutions sales team via our website or your usual sales representative.
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