4-Piperidinecarboxamide
4-Piperidinecarboxamide (CAS: 39546-32-2, C6H12N2O) is a heterocyclic organic compound with a molecular weight of 128.17 g/mol. This chemical serves as a valuable building block in organic synthesis. It is employed as a reactant in the development of various biologically active molecules, including protein modulators, enzyme inhibitors, and kinase inhibitors, contributing to advancements in medicinal chemistry research and drug discovery.
- IUPAC
- Hexahydroisonicotinamide,Isonipecotamide
- Synonyms
- HexahydroisonicotinamideIsonipecotamide
Synthesis of SMN Protein Modulators
4-Piperidinecarboxamide acts as a key reactant in the synthesis of modulators targeting the Survival Motor Neuron (SMN) protein, which is relevant for neurological research.
Development of Diaminotriazine hNav1.7 Inhibitors
This compound is utilised in the preparation of diaminotriazine derivatives that function as inhibitors of the hNav1.7 ion channel, a target for pain management therapies.
Preparation of Nitric Oxide Synthase Inhibitors
It serves as a reactant in synthesising heteroalicyclic carboxamidines investigated for their inhibitory effects on inducible nitric oxide synthase (iNOS).
Creation of Protein Kinase D Inhibitors
4-Piperidinecarboxamide is involved in the synthetic routes towards orally available naphthyridine-based inhibitors of protein kinase D (PKD).
Phosphodiesterase 5 Inhibitor Synthesis
The compound finds application as a reactant in the development of phosphodiesterase 5 (PDE5) inhibitors.
Identification of Nuclear Import Inhibitors
It is used as a reactant in the identification of small molecules that inhibit importin-β mediated nuclear import processes.
| Molecular weight | 128.17 |
|---|---|
| Empirical formula | C6H12N2O |
| Assay | 97% |
| Application | Reactant for synthesis of:• Survival motor neuron (SMN) protein modulators1• Diaminotriazine hNav1.7 inhibitors2• Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase3• Orally available naphthyridine protein kinase D inhibitors4• Phosphodiesterase 5 inhibitors5Reactant for identification of small molecular inhibitors of importin-β mediated nublear import6 |
| Melting point | 145-148 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Piperidinecarboxamide used for?
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4-Piperidinecarboxamide is primarily used as a reactant and building block in organic synthesis for the preparation of various biologically active compounds, including protein modulators and enzyme inhibitors.
What is the CAS number and formula for 4-Piperidinecarboxamide?
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The CAS number for 4-Piperidinecarboxamide is 39546-32-2, and its molecular formula is C6H12N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Piperidinecarboxamide with an assay of 97%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Piperidinecarboxamide be handled safely?
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Handling should involve wearing a dust mask (type N95), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation, as it may cause skin irritation, eye irritation, and respiratory irritation (H315, H319, H335).
How is 4-Piperidinecarboxamide packed, shipped, and exported?
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As a global supplier, Tech Serve Solutions offers 4-Piperidinecarboxamide for export, packed according to industry standards for safe transport.
How can I request a sample or quote for 4-Piperidinecarboxamide?
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To request a sample or a quote, please use the contact form on the Tech Serve Solutions website or contact our sales department directly.
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