4-Methylumbelliferyl acetate
4-Methylumbelliferyl acetate (CAS 2747-05-9; C12H10O4) is a derivative of 4-methylumbelliferone, widely employed as a fluorogenic substrate. Its acetyl ester linkage is cleaved by esterases, releasing fluorescent 4-methylumbelliferone. This property makes it invaluable in biochemical assays for enzyme activity determination, particularly for esterases. TSS supplies this compound for research and laboratory applications.
- IUPAC
- MU-Ac
Fluorogenic Enzyme Substrate
4-Methylumbelliferyl acetate serves as a substrate for detecting and quantifying esterase activity. Upon enzymatic hydrolysis, it releases the highly fluorescent 4-methylumbelliferone, enabling sensitive detection in biochemical assays.
Biochemical Research
This compound is utilized in various biochemical research settings for studying enzyme kinetics and mechanisms, particularly those involving esterase enzymes. Its fluorescence properties facilitate real-time monitoring of enzymatic reactions.
Diagnostic Assays
It can be incorporated into diagnostic assay development where esterase activity is a key marker. The generation of fluorescence provides a quantifiable signal for disease detection or biological pathway analysis.
| Molecular weight | 218.21 |
|---|---|
| Empirical formula | C12H10O4 |
| Storage temperature | −20°C |
| Melting point | 149-150 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 312 nm in methanolλex 360 nm; λem 499 nm (Reaction product) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methylumbelliferyl acetate used for?
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4-Methylumbelliferyl acetate is primarily used as a fluorogenic substrate for detecting and quantifying esterase activity in biochemical research and diagnostic assays.
What is the CAS number and formula for 4-Methylumbelliferyl acetate?
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The CAS number is 2747-05-9, and the molecular formula is C12H10O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Methylumbelliferyl acetate for research and laboratory applications. The specific assay and purity are detailed on the product's Certificate of Analysis. TSS does not represent this product as USP, BP, or EP grade.
What are the safety and handling recommendations for 4-Methylumbelliferyl acetate?
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4-Methylumbelliferyl acetate is classified with GHS07, and has a Warning signal word. It is associated with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is 4-Methylumbelliferyl acetate typically shipped or exported?
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4-Methylumbelliferyl acetate is exported by TSS adhering to all relevant international shipping regulations for chemical compounds. Specific packaging details are available upon request.
How can I request a sample or quote for 4-Methylumbelliferyl acetate?
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To request a sample or a quote, please contact the TSS sales department via the website or designated contact channels, providing your specific requirements.
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