4-Methoxy-2-(trifluoromethyl)phenylboronic acid
4-Methoxy-2-(trifluoromethyl)phenylboronic acid (CAS 313546-16-6) is an organoboron compound with the linear formula (CH3O)C6H3(CF3)B(OH)2 and a molecular weight of 219.95 g/mol. It serves as a key reactant in various organic syntheses, particularly in the development of novel pharmaceutical agents and complex organic molecules. This compound is valuable for its role in Suzuki-Miyaura cross-coupling reactions and other organometallic transformations, facilitating the construction of intricate molecular architectures.
Synthesis of Corticotropin Releasing Factor-1 Receptor Antagonists
This phenylboronic acid derivative is employed in the synthesis of pyrazine derivatives that act as corticotropin-releasing factor-1 (CRF-1) receptor antagonists, contributing to potential therapeutic developments.
C-H Functionalization of Quinones
It functions as a reactant in C-H functionalization reactions involving quinones, enabling the modification and synthesis of complex quinone-based structures.
Development of Cathepsin S Inhibitors
The compound is utilised in the synthesis of phenyl-purine-carbonitrile derivatives, which are investigated for their potential as cathepsin S inhibitors.
Ligand Synthesis
It plays a role in the synthesis of chiral bicyclooctadiene-based ligands, which are important in asymmetric catalysis and organic synthesis.
| Molecular weight | 219.95 |
|---|---|
| Linear formula | (CH3O)C6H3(CF3)B(OH)2 |
| Assay | ≥95% |
| Storage temperature | 2-8°C |
| Application | Reactant involved in:• Synthesis of pyrazine derivatives as corticotropin releasing factor-1 receptor antagonists1• C-H functionalization of quinones1• Phenyl-purine-carbonitrile derivative synthesis as cathepsin S inhibitors2• Synthesis of chiral bicyclooctadiene-based ligands3• Synthesis of corticotropin-releasing factor-1 antagonists4 |
| Melting point | 168-172 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methoxy-2-(trifluoromethyl)phenylboronic acid used for?
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4-Methoxy-2-(trifluoromethyl)phenylboronic acid is used as a reactant in various organic syntheses, including the preparation of pyrazine derivatives, C-H functionalization of quinones, synthesis of phenyl-purine-carbonitrile derivatives, and the creation of chiral ligands.
What are the CAS number and chemical formula for this compound?
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The CAS number is 313546-16-6 and the linear chemical formula is (CH3O)C6H3(CF3)B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with a minimum purity of ≥95%. It is supplied as a research or technical grade material and is not represented as USP, BP, or EP.
What are the safety and handling considerations for 313546-16-6?
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This compound is classified under WGK 3 (Germany). Please consult the Safety Data Sheet (SDS) for detailed handling, storage, and hazard information. Store at 2-8°C.
How is this chemical packed and exported by TSS?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, ensuring appropriate packing and adherence to regulations for international shipment.
How can I request a sample or quote for 4-Methoxy-2-(trifluoromethyl)phenylboronic acid?
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To request a sample or obtain a quote, please contact the Tech Serve Solutions sales team through our official website or provided contact channels.
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