4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride
4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride (CAS 80745-07-9) is a key reagent with the molecular formula C10H13ClO3S. This compound is primarily employed in organic synthesis, particularly for the protection and guanidinylation of amino groups in peptide chemistry. Its specific reactivity makes it a valuable tool for researchers in chemical biology and synthesis, enabling precise modifications in complex molecular structures.
- IUPAC
- Mtr chloride
- Synonyms
- 80745-07-9C10H13ClO3S
Peptide Synthesis
Utilised as a protecting group reagent in the synthesis of peptides. It allows for selective functionalization and manipulation of amino acid residues during chain elongation.
Guanidine Protection/Guanidinylation
This compound is instrumental in the controlled introduction of guanidine functionalities. It serves as a reliable agent for protecting guanidino groups on arginine residues or for guanidinylation reactions.
Chemical Synthesis Reagent
Acts as a versatile building block or reagent in various organic synthesis pathways. Its sulfonyl chloride moiety facilitates derivatization and coupling reactions.
Chemical Biology Research
Employed in studies involving biomolecules where precise chemical modification is required. It aids in understanding protein structure and function through targeted chemical probes.
| Molecular weight | 248.73 |
|---|---|
| Empirical formula | C10H13ClO3S |
| Assay | ≥95.0% (HPLC) |
| Storage temperature | −20°C |
| Composition | sulfur content, 12.2-13.5% |
| Melting point | 57-61 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | wet ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride used for?
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4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride is primarily used in chemical synthesis, particularly for guanidine protection/guanidinylation and in peptide chemistry. It serves as a valuable reagent in chemical biology research.
What is the CAS number and molecular formula?
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The CAS number is 80745-07-9, and the empirical formula (Hill notation) is C10H13ClO3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride with an assay of ≥95.0% (HPLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride be handled safely?
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This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection (type N100 or P3 filters), is essential. Handle with extreme caution in a well-ventilated area.
How is this chemical shipped and exported?
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4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride is shipped in wet ice to maintain stability and is exported globally by Tech Serve Solutions, adhering to all relevant transport regulations, including UN 3261, Class 8, Packing Group III.
How can I request a sample or quote for this product?
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To request a sample or a quote, please contact our sales team through the website or via direct email, specifying the product name and CAS number (80745-07-9).
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