4-(Hydroxymethyl)phenylboronic acid
4-(Hydroxymethyl)phenylboronic acid (CAS: 59016-93-2) is an organoboronic acid with the linear formula HOCH2C6H4B(OH)2 and a molecular weight of 151.96 g/mol. This compound serves as a key reactant in organic synthesis, particularly in the creation of complex molecules for pharmaceutical research. Its primary utility lies in its participation in Suzuki coupling reactions and other transformations for developing novel therapeutic agents.
- IUPAC
- α-Hydroxy-p-tolueneboronic acid,4-Hydroxymethylbenzeneboronic acid
- Synonyms
- 4-Borono-benzyl alcohol4-(Dihydroxyboranyl)benzyl alcohol
Synthesis of mTOR Kinase Inhibitors
This boronic acid is a reactant in the synthesis of imidazo[4,5-b]pyrazin-2-ones, which are investigated for their potential as mTOR kinase inhibitors.
Development of HIV Protease Inhibitors
It is employed as a reactant in the development of human immunodeficiency virus protease inhibitors, including those active against resistant viral strains.
Suzuki Coupling Reactions
4-(Hydroxymethyl)phenylboronic acid is a valuable substrate in Suzuki coupling reactions, a fundamental cross-coupling methodology in organic chemistry.
Copper-Catalyzed Transformations
The compound participates in copper-catalyzed reactions, including transformations from arylboronic acids conducted in aqueous media.
Polyurethane Synthesis
It is involved in the synthesis of polyurethanes that incorporate spindle-type chromophores, relevant for materials science applications.
| Molecular weight | 151.96 |
|---|---|
| Linear formula | HOCH2C6H4B(OH)2 |
| Application | Reactant involved in the synthesis of biologically active compounds including:• Imidazo[4,5-b]pyrazin-2-ones for use as mTOR kinase inhibitors1• Human immunodificiency virus protease inhibitors with activity against resistant viruses2Reactant involved in:• Suzuki coupling reactions2,3• Copper-catalyzed transformation from arylboronic acids in water4Involved in the synthesis of polyurethane containing spindle-type chromophores5 |
| Melting point | 251-256 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Hydroxymethyl)phenylboronic acid used for?
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4-(Hydroxymethyl)phenylboronic acid is used as a reactant in organic synthesis, notably for creating biologically active compounds such as potential mTOR kinase inhibitors and HIV protease inhibitors. It is also utilized in Suzuki coupling reactions and copper-catalyzed transformations.
What is the CAS number and linear formula for 4-(Hydroxymethyl)phenylboronic acid?
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The CAS number is 59016-93-2, and the linear formula is HOCH2C6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product for research and chemical synthesis purposes. The specific assay and grade will be detailed on the Certificate of Analysis provided with the product. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
What are the safety and handling precautions for 4-(Hydroxymethyl)phenylboronic acid?
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Handling this compound requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Refer to the Safety Data Sheet (SDS) for comprehensive hazard information and handling procedures. This compound has a WGK rating of 3 in Germany.
How is 4-(Hydroxymethyl)phenylboronic acid packed, shipped, and exported?
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Tech Serve Solutions packs and ships chemicals in compliance with all relevant national and international regulations. We are experienced global exporters of fine chemicals and laboratory reagents.
How can I request a sample or a quote for 4-(Hydroxymethyl)phenylboronic acid?
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To request a sample or a quote, please contact our sales department via the details provided on our website, referencing the product name and CAS number 59016-93-2.
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