1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile
1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile (CAS 28049-61-8; molecular formula C11H10ClN, molar mass 191.66 g/mol) is a quaternary cyclobutane nitrile bearing a 4-chlorophenyl group. Supplied as a 97% assay research-grade building block, it is a versatile organic intermediate. The strained cyclobutane ring and reactive nitrile make it useful in chemical synthesis, where it serves as a precursor for carboxylic acids, amines and other functionalised cyclobutane scaffolds in pharmaceutical and fine-chemical research.
- Synonyms
- 1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile1-(4-Chlorophenyl)cyclobutanecarbonitrile1-(4-Chlorophenyl)cyclobutane-1-carbonitrile4-ChlorophenylcyclobutanecarbonitrileCAS 28049-61-8MFCD00065239
Pharmaceutical and fine-chemical intermediate
Used as a building block in multi-step organic synthesis toward more complex molecules. The chlorophenyl-substituted cyclobutane core is a useful scaffold in medicinal-chemistry and process-research programmes.
Nitrile functional-group chemistry
The nitrile group can be transformed into carboxylic acids, amides, amines, ketones or tetrazoles, providing a single starting point for several downstream functionalities.
Cyclobutane scaffold construction
Supplies a pre-formed, quaternary cyclobutane ring, allowing chemists to introduce the strained four-membered carbocycle without building it in situ.
Research and laboratory reagent
Employed in academic and industrial laboratories for method development, route scouting and the preparation of reference compounds where a defined cyclobutane nitrile is required.
| Molecular weight | 191.66 |
|---|---|
| Linear formula | ClC6H4C4H6CN |
| Assay | 97% |
| Boiling point | 295 °C(lit.) |
| Density | 1.137 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.548(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile used for?
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It is used mainly as an organic building block and synthetic intermediate. The reactive nitrile and 4-chlorophenyl cyclobutane scaffold make it valuable for preparing carboxylic acids, amines and related functionalised cyclobutane compounds in pharmaceutical and fine-chemical research.
What is the CAS number and molecular formula of 1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile?
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The CAS number is 28049-61-8 and the molecular formula is C11H10ClN (linear formula ClC6H4C4H6CN), with a molecular weight of 191.66 g/mol. Its EC number is 248-799-7 and MDL number MFCD00065239.
What grade and purity does Tech Serve Solutions supply?
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We supply this compound as a research/technical-grade building block with a typical assay of 97%. Reported physical data include a boiling point of about 295 °C, density 1.137 g/mL at 25 °C and refractive index n20/D 1.548. We do not represent it as a USP, BP or EP pharmacopoeial grade.
What are the safety and handling requirements?
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It is classified under GHS07 with the signal word Warning and hazard statements H302, H312 and H332 — harmful if swallowed, in contact with skin or if inhaled. Use eye and face protection, gloves and suitable respiratory protection (P280), avoid dust and vapour, and consult the Safety Data Sheet before use. WGK water-hazard class is 3.
How is 1-(4-Chlorophenyl)-1-cyclobutanecarbonitrile packed, shipped and exported?
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It is packed in securely sealed containers with sizing from laboratory quantities to bulk, each batch labelled and accompanied by a Certificate of Analysis and Safety Data Sheet. As a global supplier and exporter, Tech Serve Solutions arranges compliant documentation and transport for worldwide despatch.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and full documentation. Samples can be arranged for evaluation where appropriate.
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