(+)-Methyl (R)-2-chloropropionate

CAS 77287-29-7CH3CH(Cl)CO2CH3Chemical Synthesis

(+)-Methyl (R)-2-chloropropionate (CAS: 77287-29-7), with the molecular formula CH3CH(Cl)CO2CH3 and a molecular weight of 122.55 g/mol, is a chiral ester. It is primarily utilised as a valuable chiral building block in asymmetric synthesis. This compound serves as a key starting material for the introduction of specific stereochemistry in complex organic molecules, facilitating the synthesis of enantiomerically pure products for various chemical applications.

IUPAC: (R)-(+)-2-Chloropropionic acid methyl ester

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(+)-Methyl (R)-2-chloropropionate (CH3CH(Cl)CO2CH3) — chemical structure, CAS 77287-29-7; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral Building BlocksEstersOrganic Building Blocks

01 /Applications

Chiral Building Block

Serves as a fundamental chiral intermediate in the synthesis of enantiomerically enriched compounds. Its defined stereochemistry is crucial for constructing complex molecules with precise spatial arrangements, particularly in pharmaceutical and agrochemical research.

Asymmetric Synthesis

Utilised in asymmetric synthesis pathways to create chiral centres in target molecules. This ester allows for stereoselective transformations, enabling the production of single enantiomers required for biologically active compounds.

Organic Synthesis

A versatile reagent in general organic synthesis, offering a readily available source of a chiral alpha-chloroester moiety. It participates in various reactions, including nucleophilic substitutions and ester transformations.

02 /Properties

Molecular weight	122.55
Linear formula	CH3CH(Cl)CO2CH3
Assay	98%
Boiling point	132-134 °C(lit.)
Density	1.152 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.417(lit.)
Optical activity	[α]20/D +26°, neat
Optical purity	ee: 95% (GLC)
Application	Chiral starting material

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	37 °C / 98.6 °F
Transport (UN / ADR)	UN 2933 3 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	10-36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

77287-29-7

MDL number

MFCD00062940

PubChem substance

24856784

Beilstein registry

1720590

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (+)-Methyl (R)-2-chloropropionate used for?

(+)-Methyl (R)-2-chloropropionate is primarily used as a chiral building block and starting material in asymmetric synthesis for creating enantiomerically pure compounds.

What are the CAS number and formula for (+)-Methyl (R)-2-chloropropionate?

The CAS number is 77287-29-7 and the molecular formula is CH3CH(Cl)CO2CH3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies (+)-Methyl (R)-2-chloropropionate with an assay of 98%. This product is not represented as USP, BP, EP, or other pharmacopoeia grades.

How should (+)-Methyl (R)-2-chloropropionate be handled safely?

This compound is a flammable liquid and vapour (H226), causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment including eyeshields, faceshields, and gloves in a well-ventilated area. Avoid ignition sources.

How is (+)-Methyl (R)-2-chloropropionate packed, shipped, and exported?

Products are carefully packed according to international shipping regulations and exported globally by Tech Serve Solutions. Specific packaging details are available upon request for UN 2933, 3, PGIII shipments.

How can I request a quote or sample for (+)-Methyl (R)-2-chloropropionate?

To request a quote or sample, please use the contact form on our website or call our sales department, quoting the product name and CAS number 77287-29-7.