2-Thienyllithium solution
2-Thienyllithium solution (CAS: 2786-07-4, Formula: C4H3LiS) is a vital organolithium reagent with a molecular weight of 90.07 g/mol. Supplied as a 1.0 M solution in THF/hexanes, it is highly reactive and pyrophoric. This compound is indispensable in organic synthesis, particularly for introducing the 2-thienyl moiety into complex molecules, serving as a key building block in pharmaceuticals and advanced materials research.
Organic Synthesis
2-Thienyllithium is a powerful nucleophile used for C-C bond formation via reactions with electrophiles such as aldehydes, ketones, esters, and alkyl halides. It enables the regioselective functionalization of thiophene rings.
Pharmaceutical Intermediate
It serves as a crucial intermediate in the synthesis of various pharmacologically active compounds containing the thiophene core, which is present in numerous marketed drugs.
Materials Science
This reagent is employed in the development of novel organic electronic materials, including conducting polymers and organic semiconductors, where the thiophene unit imparts desirable electronic properties.
| Molecular weight | 90.07 |
|---|---|
| Empirical formula | C4H3LiS |
| Density | 0.829 g/mL at 25 °C |
| Concentration | 1.0 M in THF/hexanes |
Hazard statements
- H225Highly flammable liquid and vapour
- H304May be fatal if swallowed and enters airways
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
- H335May cause respiratory irritation
- H336May cause drowsiness or dizziness
- H351Suspected of causing cancer
- H361F
- H373May cause damage to organs through prolonged exposure
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -30 °C / -22 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn,N |
| Risk statements (R) | 11-14-19-36/37/38-40-48/20-51/53-62-65-67 |
| Safety statements (S) | 16-26-36/37-61-62 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Thienyllithium solution used for?
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2-Thienyllithium solution is primarily used in organic synthesis for introducing the 2-thienyl group into molecules, serving as an intermediate in the production of pharmaceuticals, agrochemicals, and advanced materials. Its strong nucleophilicity makes it valuable for C-C bond formation.
What are the CAS number and chemical formula for 2-Thienyllithium solution?
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The CAS number for 2-Thienyllithium solution is 2786-07-4, and its empirical formula is C4H3LiS.
What grade and purity does Tech Serve Solutions supply for 2-Thienyllithium solution?
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Tech Serve Solutions supplies 2-Thienyllithium solution as a 1.0 M concentration in THF/hexanes. We do not specify USP, BP, or EP grades unless explicitly stated in the product data; this product is typically considered a research or technical grade.
How should 2-Thienyllithium solution be handled safely?
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2-Thienyllithium solution is extremely hazardous. It is a flammable liquid and vapour (H225), can cause severe skin burns and eye damage (H314), and is harmful if swallowed or inhaled (H304, H332). It reacts violently with water and may form explosive peroxides. Strict exclusion of air and moisture, use of appropriate PPE (gloves, eyeshields, face shield, respirator), and working under an inert atmosphere are essential.
How is 2-Thienyllithium solution packed, shipped, and exported?
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As a hazardous material (UN 3399, Class 4.3), 2-Thienyllithium solution is carefully packed in compliant containers. Shipments adhere to international dangerous goods regulations for air, sea, and land transport, ensuring safe and secure export globally.
How can I request a quote or sample for 2-Thienyllithium solution?
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To request a quote or a sample of 2-Thienyllithium solution, please contact our sales department via the website or direct email, providing your contact details and the required quantity.
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