1-(4-Chlorobenzhydryl)piperazine
1-(4-Chlorobenzhydryl)piperazine (CAS 303-26-4), also known as norchlorcyclizine, is a halogenated heterocyclic building block with the molecular formula C17H19ClN2 and a molar mass of 286.80 g/mol. Supplied by Tech Serve Solutions as a technical-grade material of around 90% assay, it is a mono-substituted piperazine bearing a 4-chlorobenzhydryl group. It is used principally as a synthetic intermediate in the preparation of piperazine antihistamines, notably cetirizine.
- IUPAC
- (RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine,NSC 86164,Norchlorcyclizine
- Synonyms
- 1-(4-Chlorobenzhydryl)piperazine(RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazineNorchlorcyclizineNSC 861641-[(4-Chlorophenyl)(phenyl)methyl]piperazineCAS 303-26-4
Pharmaceutical intermediate for cetirizine
This compound is an established building block in the synthesis of cetirizine and related piperazine-based antihistamines. The free piperazine nitrogen provides a convenient handle for onward alkylation and acylation.
Heterocyclic building block for chemical synthesis
As a mono-substituted piperazine, it serves as a versatile scaffold in medicinal and process chemistry. The 4-chlorobenzhydryl substituent and secondary amine support a range of downstream derivatisations.
Halogenated piperazine scaffold
The aryl chloride and diaryl-methine core make it useful where a defined halogenated, lipophilic piperazine fragment is required. It is well suited to structure-activity studies around the benzhydrylpiperazine motif.
Reference and research material
Norchlorcyclizine is a documented compound (NSC 86164) of interest in research settings. It is supplied for laboratory and process-development use as a technical-grade reagent.
| Molecular weight | 286.80 |
|---|---|
| Empirical formula | C17H19ClN2 |
| Assay | 90% |
| Grade | technical grade |
| Boiling point | 178-180 °C/0.5 mmHg(lit.) |
| Application | Cetirizine |
| Melting point | 65-70 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Chlorobenzhydryl)piperazine used for?
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It is used principally as a synthetic intermediate in the preparation of piperazine antihistamines, notably cetirizine. As a mono-substituted, halogenated piperazine building block it also serves wider medicinal and process-chemistry synthesis.
What is the CAS number and molecular formula of 1-(4-Chlorobenzhydryl)piperazine?
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The CAS number is 303-26-4 and the molecular formula is C17H19ClN2, with a molecular weight of 286.80 g/mol. The EC number is 206-137-4 and the MDL number is MFCD00005965.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(4-Chlorobenzhydryl)piperazine as a technical-grade material with a typical assay of around 90%. We do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis is provided with each batch.
What are the safety and handling requirements for 1-(4-Chlorobenzhydryl)piperazine?
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It carries the GHS07 pictogram with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves and eye protection, use adequate ventilation or suitable respiratory protection, and avoid breathing dust. It is classified WGK 3 (highly hazardous to water), so prevent release to drains and watercourses.
Is 1-(4-Chlorobenzhydryl)piperazine a controlled substance?
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The data supplied to us does not flag this compound as a scheduled or controlled substance. Customers remain responsible for confirming the regulatory status applicable in their own jurisdiction prior to import and use.
How is 1-(4-Chlorobenzhydryl)piperazine packed, shipped and exported?
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It is packed in securely sealed, appropriately labelled containers sized to order, from laboratory quantities to bulk. Each consignment ships with a certificate of analysis and safety data sheet, and is exported worldwide in line with applicable transport and customs requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, grade and delivery destination, and our team will respond with availability, lead time and documentation. Samples can be arranged where appropriate for evaluation.
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