4-(Maleinimido)phenyl isocyanate
4-(Maleinimido)phenyl isocyanate (CAS: 123457-83-0) is a bifunctional organic compound with the molecular formula C11H6N2O3 and a molecular weight of 214.18 g/mol. It combines a reactive maleimide group, known for its efficient reaction with thiols, and an isocyanate group, which readily reacts with nucleophiles such as amines and alcohols. This dual reactivity makes it a valuable building block in chemical synthesis and bioconjugation.
- IUPAC
- N-(4-Isocyanatophenyl)maleimide,PMPI
- Synonyms
- N-(4-Isocyanatophenyl)maleimidePMPI
Bioconjugation
The maleimide moiety enables site-specific conjugation to thiol-containing biomolecules like proteins and peptides. The isocyanate group can then be used to attach other molecules or surfaces, facilitating the creation of novel bioconjugates.
Polymer Chemistry
This compound can serve as a monomer or crosslinking agent in polymer synthesis. The isocyanate group can react with hydroxyl or amine functionalities in polymers, while the maleimide group can be involved in subsequent crosslinking reactions or polymer modifications.
Surface Modification
Its dual functionality allows for the covalent attachment to surfaces functionalized with thiols or amines. This is useful for creating functionalized surfaces for biosensors, chromatography media, or other advanced materials.
Organic Synthesis Intermediate
As a versatile intermediate, it can be employed in multi-step organic synthesis pathways where the sequential or selective reaction of its two distinct functional groups is required.
| Molecular weight | 214.18 |
|---|---|
| Empirical formula | C11H6N2O3 |
| Assay | ≥97.0% (CHN) |
| Grade | purum |
| Melting point | 120-125 °C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P342
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38-42 |
| Safety statements (S) | 22-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Maleinimido)phenyl isocyanate used for?
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4-(Maleinimido)phenyl isocyanate is primarily used in bioconjugation, polymer chemistry, surface modification, and as an intermediate in organic synthesis due to its dual reactive maleimide and isocyanate functionalities.
What is the CAS number and formula for 4-(Maleinimido)phenyl isocyanate?
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The CAS number is 123457-83-0, and the empirical formula is C11H6N2O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at a purity of ≥97.0% (CHN) with a 'purum' grade. We do not represent it as USP, BP, or EP grade.
How should 4-(Maleinimido)phenyl isocyanate be handled?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, a face shield, and gloves. Ensure adequate ventilation. It is harmful if swallowed, inhaled, or in contact with skin, and can cause skin and eye irritation, and allergic skin reactions.
Is 4-(Maleinimido)phenyl isocyanate a controlled substance?
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The provided data does not indicate that 4-(Maleinimido)phenyl isocyanate is a controlled substance.
How is 4-(Maleinimido)phenyl isocyanate packed and shipped?
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We pack and ship this chemical in compliance with all relevant regulations for safe transport, catering to both domestic and international export requirements.
How can I request a sample or quote for 4-(Maleinimido)phenyl isocyanate?
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Please contact our sales team through the website or via email to request a sample or a formal quotation for 4-(Maleinimido)phenyl isocyanate.
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