(+)-Thalidomide

CAS 2614-06-4C13H10N2O4Biochemicals & Reagents

(+)-Thalidomide (CAS: 2614-06-4, C13H10N2O4) is a bioactive molecule with a molecular weight of 258.23 g/mol. Primarily recognized for its role in studying angiogenesis and cellular processes, it is utilized in research settings to investigate teratogenic effects and cellular signaling pathways. Tech Serve Solutions supplies this compound as a white to beige powder, meeting a purity of ≥98% via HPLC. It is stored at room temperature and is soluble in DMSO.

IUPAC: R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

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(+)-Thalidomide (C13H10N2O4) — chemical structure, CAS 2614-06-4; Life Science, fine chemical supplied by Tech Serve Solutions

Angiogenesis RegulatorsApplication IndexBioactive Small MoleculesBiochemicals and ReagentsCelgeneCell BiologyCell Signaling EnzymesEnzymesInhibitorsand Substrates

01 /Applications

Teratogenic Studies

Used in research to investigate the teratogenic effects on embryonic development, particularly limb defects, by stabilizing PTEN and influencing apoptosis pathways.

Cellular Signaling Research

Investigated for its role in cellular resistance mechanisms, such as glutathione-mediated teratogenic resistance in embryonic models.

Angiogenesis Regulation Studies

Applied in research to understand its influence on angiogenesis, contributing to studies on blood vessel formation and related cellular processes.

02 /Properties

Molecular weight	258.23
Empirical formula	C13H10N2O4
Assay	≥98% (HPLC)
Form	powder
Colour	white to beige
Solubility	DMSO: soluble15 mg/mL, clear
Storage temperature	room temp
Application	Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis1. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos2.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H302Harmful if swallowed
H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use
P308IF exposed or concerned

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	61-22
Safety statements (S)	53-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2614-06-4

MDL number

MFCD00210220

05 /Additional specifications

Gene Information	human ... LITAF(9516), TNF(7124)mouse ... Nos2(18126)rat ... Nos1(24598)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is (+)-Thalidomide used for?

(+)-Thalidomide is used in research to study teratogenic effects, cellular signaling pathways, and angiogenesis regulation. It has been employed in models to investigate limb defects and resistance mechanisms.

What is the CAS number and formula for (+)-Thalidomide?

The CAS number for (+)-Thalidomide is 2614-06-4, and its empirical formula is C13H10N2O4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies (+)-Thalidomide with an assay of ≥98% (HPLC). This is a research-grade chemical and is not represented as USP, BP, EP, or pharmacopoeia grade.

How should (+)-Thalidomide be handled safely?

(+)-Thalidomide is classified with Danger signal word and carries hazard statements H302 (Harmful if swallowed) and H360 (May damage fertility or the unborn child). Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and suitable respiratory protection, must be used. Handle with extreme caution in a well-ventilated area, and consult the Safety Data Sheet before use.

Is (+)-Thalidomide a controlled substance?

Yes, (+)-Thalidomide is a restricted substance. Specific regulations apply to its handling and distribution due to its teratogenic properties and therapeutic applications.

How is (+)-Thalidomide typically packed and shipped?

(+)-Thalidomide is supplied as a powder and is carefully packed for domestic and international shipment according to regulatory requirements for hazardous materials.

How can I request a quote or sample for (+)-Thalidomide?

To request a quote or a sample of (+)-Thalidomide, please contact our sales team through the website or by phone, providing your details and the required quantity.