4-(Methanesulfonyl)phenylboronic acid
4-(Methanesulfonyl)phenylboronic acid (CAS: 149104-88-1), with the linear formula (H3CSO2)C6H4B(OH)2 and a molecular weight of 200.02 g/mol, is a specialised aryl boronic acid derivative. It serves as a key reagent in various organic synthesis applications, particularly in sequential Suzuki cross-coupling reactions and the preparation of complex molecules such as potential anti-malarial agents and kinase inhibitors. Supplied by TSS with an assay of ≥95.0%.
- IUPAC
- 4-(Methanesulfonyl)benzeneboronic acid,4-(Methylsulfonyl)phenylboronic acid,4-Methansulfonylphenylboronic acid
- Synonyms
- 4-(Methanesulfonyl)benzeneboronic acid4-(Methylsulfonyl)phenylboronic acid4-Methansulfonylphenylboronic acid
Suzuki Cross-Coupling Reactions
This compound is a valuable reagent for sequential Suzuki cross-coupling reactions, enabling the formation of carbon-carbon bonds in complex organic synthesis pathways.
Preparation of Pharmaceutical Intermediates
It is used in the preparation of biaryl sulfone derivatives, which may act as antagonists of the histamine H3 receptor, and novel kinase inhibitor scaffolds with potential antitumor effects.
Organometallic Synthesis
Utilised in directed metalation and regioselective functionalisation of heterocyclic compounds, as well as in palladium-catalyzed cross-coupling processes.
Heterocycle Synthesis
Applications include Barton-Zard pyrrole cyclocondensations and the preparation of hydropyranopyrazines via chloropyrazinecarboxaldehyde.
| Molecular weight | 200.02 |
|---|---|
| Linear formula | (H3CSO2)C6H4B(OH)2 |
| Assay | ≥95.0% |
| Application | Reagent used for• Sequential Suzuki cross-coupling reactions1 • Copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids2 • Directed metalation and regioselective functionalization of 3-bromofuran and related heterocycles3 • Barton-Zard pyrrole cyclocondensations and Baeyer-Villiger oxidations4 • Diplar cycloaddition and palladium-catalyzed cross-coupling processes5 Reagent used in Preparation of• Diarylaminopyridines as potential anti-malarial agents1 • Hydropyranopyrazine via chloropyrazinecarboxaldehyde and olefination6 • Biaryl sulfone derivatives as antagonists of the histamine H3 receptor7 • Novel kinase inhibitor scaffolds with potential antitumor effects8,9 • Hepatitis C virus inhibition activity of N- |
| Melting point | 289-293 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Methanesulfonyl)phenylboronic acid used for?
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4-(Methanesulfonyl)phenylboronic acid is used as a reagent in sequential Suzuki cross-coupling reactions, copper-catalyzed oxidative trifluoromethylthiolation, directed metalation of heterocycles, and in the preparation of various biologically active compounds including potential anti-malarial agents and kinase inhibitors.
What is the CAS number and formula for 4-(Methanesulfonyl)phenylboronic acid?
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The CAS number is 149104-88-1, and its linear formula is (H3CSO2)C6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Methanesulfonyl)phenylboronic acid with an assay of ≥95.0%. This is a technical/research grade material and TSS does not represent it as USP/BP/EP.
What are the safety considerations when handling 4-(Methanesulfonyl)phenylboronic acid?
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According to the supplied data, this compound has a WGK (German water hazard class) of 3, indicating it is hazardous to aquatic life. Handle with appropriate personal protective equipment in a well-ventilated area.
How is 4-(Methanesulfonyl)phenylboronic acid packed and shipped?
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Tech Serve Solutions, as a global supplier and exporter, ensures appropriate packaging and shipping methods that comply with international regulations for chemical transport.
How can I request a sample or quote for 4-(Methanesulfonyl)phenylboronic acid?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number (149104-88-1).
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