4-Fluoro-2-nitroaniline
4-Fluoro-2-nitroaniline (CAS: 364-78-3), with the molecular formula FC6H3(NO2)NH2 and a molecular weight of 156.11 g/mol, is a fluorinated aromatic amine. It serves as a valuable building block in organic synthesis. This compound is utilised as a starting reagent in the preparation of more complex molecules, particularly within the fine chemical and pharmaceutical intermediate sectors. Its structure allows for further chemical transformations, making it a key component in various synthetic routes.
Synthesis of Fluorinated Anilines
4-Fluoro-2-nitroaniline is employed as a precursor in the synthesis of substituted anilines. For instance, it has been used as a starting reagent in the preparation of 4-fluoro-N-ethyl-2-nitroaniline, showcasing its utility in creating functionalized aromatic compounds.
Intermediate for Organic Synthesis
This compound functions as a versatile intermediate in the development of diverse organic molecules. Its specific substitution pattern, featuring both a fluorine atom and a nitro group alongside an amine, enables participation in a range of chemical reactions crucial for creating complex structures.
Pharmaceutical Building Block
As a fluorinated aromatic building block, 4-Fluoro-2-nitroaniline is instrumental in the synthesis of potential pharmaceutical agents. Its inclusion in synthetic pathways allows for the introduction of fluorine, a common element in modern drug discovery due to its ability to modulate pharmacokinetic properties.
Research and Development
Researchers utilise 4-Fluoro-2-nitroaniline in academic and industrial laboratories for exploring novel synthetic methodologies and developing new chemical entities. Its availability as a reagent supports ongoing research in areas such as medicinal chemistry and materials science.
| Molecular weight | 156.11 |
|---|---|
| Linear formula | FC6H3(NO2)NH2 |
| Assay | 97% |
| Application | 4-Fluoro-2-nitroaniline was used as starting reagent in the synthesis of 4-fluoro-N-ethyl-2-nitroaniline1 and N-(4-fluoro-2-nitrophenyl)-β-alanine2. |
| Melting point | 90-94 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 89 °C / 192.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-2-nitroaniline used for?
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4-Fluoro-2-nitroaniline is primarily used as a starting reagent in organic synthesis, particularly for preparing other fluorinated aromatic compounds, including pharmaceutical intermediates and research chemicals.
What are the CAS number and molecular formula for 4-Fluoro-2-nitroaniline?
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The CAS number for 4-Fluoro-2-nitroaniline is 364-78-3, and its molecular formula is FC6H3(NO2)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluoro-2-nitroaniline with an assay of 97%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade; it is intended for research and chemical synthesis purposes.
How should 4-Fluoro-2-nitroaniline be handled safely?
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Handle 4-Fluoro-2-nitroaniline with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation, and be aware of its hazards: H302 (Harmful if swallowed), H312 (Harmful in contact with skin), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H332 (Harmful if inhaled), and H335 (May cause respiratory irritation).
How is 4-Fluoro-2-nitroaniline packed and exported?
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Tech Serve Solutions carefully packs and exports chemicals, adhering to all relevant regulations for safe transport globally. Specific packaging details are available upon request.
How can I request a sample or quote for 4-Fluoro-2-nitroaniline?
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To request a sample or quote for 4-Fluoro-2-nitroaniline, please contact our sales team via the website or direct email, providing your specific requirements.
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