4-Fluoro-2-methylphenylboronic acid

CAS 139911-29-8FC6H3(CH3)B(OH)2Chemical Synthesis

Tech Serve Solutions offers 4-Fluoro-2-methylphenylboronic acid (CAS: 139911-29-8), a versatile organoboron compound with the formula FC6H3(CH3)B(OH)2 and a molecular weight of 153.95 g/mol. This disubstituted aryl boronic acid is a key intermediate in organic synthesis, primarily utilised as a reactant in palladium-catalyzed cross-coupling reactions, including the Suzuki-Miyaura coupling. Its precise structure makes it valuable for introducing the 2-methyl-4-fluorophenyl moiety into complex molecules.

IUPAC: 2-Methyl-4-fluorophenylboronic acid
Synonyms: 2-Methyl-4-fluorophenylboronic acid

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4-Fluoro-2-methylphenylboronic acid (FC6H3(CH3)B(OH)2) — chemical structure, CAS 139911-29-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Suzuki-Miyaura Cross-Coupling Reactions

4-Fluoro-2-methylphenylboronic acid serves as a crucial coupling partner in Suzuki-Miyaura reactions. This palladium-catalyzed cross-coupling facilitates the formation of carbon-carbon bonds, enabling the synthesis of biaryl compounds and other complex organic structures.

Tandem Cross-Coupling and Cyclization

This boronic acid is employed in tandem palladium-catalyzed processes, combining Suzuki cross-coupling with subsequent cyclization steps. Such reactions are efficient for constructing polycyclic aromatic systems and other fused ring structures.

Organic Synthesis Intermediate

As a functionalised aryl boronic acid, 4-Fluoro-2-methylphenylboronic acid is a valuable building block in synthetic organic chemistry. It allows for the precise introduction of a 2-methyl-4-fluorophenyl group into target molecules across various research and development fields.

02 /Properties

Molecular weight	153.95
Linear formula	FC6H3(CH3)B(OH)2
Application	Reactant for:• Tandem palladium-catalyzed Suzuki cross-coupling and cyclization reactions1• Suzuki-Miyaura reactions2,3
Melting point	191-196 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

139911-29-8

MDL number

MFCD02093072

PubChem substance

24880250

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 4-Fluoro-2-methylphenylboronic acid used for?

4-Fluoro-2-methylphenylboronic acid is primarily used as a reactant in palladium-catalyzed Suzuki cross-coupling and Suzuki-Miyaura reactions, including tandem cross-coupling and cyclization processes for organic synthesis.

What is the CAS number and chemical formula for 4-Fluoro-2-methylphenylboronic acid?

The CAS number is 139911-29-8, and its chemical formula is FC6H3(CH3)B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 4-Fluoro-2-methylphenylboronic acid typically at research or technical grade. We do not represent this product as USP, BP, or EP grade unless explicitly stated.

What are the safety and handling precautions for 4-Fluoro-2-methylphenylboronic acid?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK Germany 3, indicating a significant hazard to water.