4′-Fluoro-2′-hydroxyacetophenone
4′-Fluoro-2′-hydroxyacetophenone (CAS 1481-27-2) is a fluorinated organic building block with the linear formula FC<sub>6</sub>H<sub>3</sub>(OH)COCH<sub>3</sub> and a molecular weight of 154.14 g/mol. This ketone is primarily utilised in chemical synthesis, particularly in the preparation of complex heterocyclic compounds. Its structure, featuring both a fluorine atom and a hydroxyl group on an acetophenone core, makes it a valuable intermediate for introducing specific functionalities in medicinal chemistry and materials science research.
Synthesis of Benzo[b]furans
This compound serves as a key precursor in the recent preparation of medicinally active benzo[b]furans. The fluorinated acetophenone structure facilitates cyclisation reactions leading to these important heterocyclic systems.
Preparation of Thiophenes
It is also employed in the synthesis of thiophene derivatives. The compound's reactive functional groups enable its transformation into various substituted thiophenes with potential pharmaceutical applications.
Fluorinated Organic Synthesis
As a fluorinated building block, 4′-Fluoro-2′-hydroxyacetophenone is instrumental in introducing fluorine atoms into organic molecules. This is crucial for modifying the physicochemical and biological properties of target compounds.
| Molecular weight | 154.14 |
|---|---|
| Linear formula | FC6H3(OH)COCH3 |
| Assay | 98% |
| Application | Used recently in the preparation of medicinally active benzo[b]furans and thiophenes.1 |
| Melting point | 31-35 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 99 °C / 210.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4′-Fluoro-2′-hydroxyacetophenone used for?
+
4′-Fluoro-2′-hydroxyacetophenone (CAS 1481-27-2) is used in chemical synthesis, notably for preparing medicinally active benzo[b]furans and thiophenes, and as a fluorinated organic building block.
What are the CAS number and molecular formula for 4′-Fluoro-2′-hydroxyacetophenone?
+
The CAS number is 1481-27-2 and the linear molecular formula is FC<sub>6</sub>H<sub>3</sub>(OH)COCH<sub>3</sub>.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 4′-Fluoro-2′-hydroxyacetophenone with an assay of 98%. This is a research or technical grade material; TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.
How should 4′-Fluoro-2′-hydroxyacetophenone be handled safely?
+
4′-Fluoro-2′-hydroxyacetophenone is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, in a well-ventilated area. Avoid breathing dust.
Is this chemical supplied internationally by TSS?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4′-Fluoro-2′-hydroxyacetophenone.
How can I request a quote or sample for 4′-Fluoro-2′-hydroxyacetophenone?
+
To request a quote or sample, please contact the Tech Serve Solutions sales team through the website or by phone.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis