4-(Difluoromethoxy)phenyl isothiocyanate
4-(Difluoromethoxy)phenyl isothiocyanate (CAS: 189281-92-3) is a fluorinated organic compound with the linear formula F₂HOCC₆H₄NCS and a molecular weight of 201.19 g/mol. This chemical serves as a valuable building block in organic synthesis, particularly in the creation of novel molecules. It is characterised by its isothiocyanate functional group and difluoromethoxy substituent, making it a useful intermediate for introducing these moieties into larger structures.
Organic Synthesis Intermediate
Utilised as a versatile building block in the synthesis of complex organic molecules. Its reactive isothiocyanate group allows for facile derivatization, enabling the construction of various heterocyclic compounds and functionalised aromatic systems.
Pharmaceutical Research
Can be employed in the development of new pharmaceutical agents. The difluoromethoxy group can influence the pharmacokinetic properties of drug candidates, while the isothiocyanate moiety can be a precursor to biologically active structures.
Agrochemical Development
Serves as an intermediate in the synthesis of potential agrochemical compounds. The incorporation of fluorine can sometimes enhance the efficacy or modify the environmental profile of pesticides or herbicides.
| Molecular weight | 201.19 |
|---|---|
| Linear formula | F2CHOC6H4NCS |
| Assay | 97% |
| Boiling point | 252-255 °C(lit.) |
| Density | 1.33 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.584(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 1760 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Difluoromethoxy)phenyl isothiocyanate used for?
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4-(Difluoromethoxy)phenyl isothiocyanate (CAS: 189281-92-3) is primarily used as a building block and intermediate in organic synthesis, including pharmaceutical and agrochemical research and development.
What is the CAS number and formula for 4-(Difluoromethoxy)phenyl isothiocyanate?
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The CAS number is 189281-92-3 and the linear formula is F₂HOCC₆H₄NCS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Difluoromethoxy)phenyl isothiocyanate with an assay of 97%. We do not represent this product as USP, EP, or BP grade. Further details on specific grades available can be confirmed upon request.
How should 4-(Difluoromethoxy)phenyl isothiocyanate be handled?
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This compound is classified as Dangerous (GHS05, Danger, H314) and causes severe skin burns and eye damage. Appropriate personal protective equipment, including face shields, gloves, goggles, and suitable respiratory protection, must be used. Handle only in a well-ventilated area or under a fume hood. Refer to the Safety Data Sheet for comprehensive handling information.
How is this chemical shipped and exported?
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As per UN 1760, 8/PGII regulations, 4-(Difluoromethoxy)phenyl isothiocyanate is shipped as a corrosive material. Tech Serve Solutions is experienced in exporting chemicals globally, ensuring compliance with all relevant transport and customs regulations.
How can I request a sample or quote?
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To request a sample or a quotation for 4-(Difluoromethoxy)phenyl isothiocyanate, please use the 'Request a Quote' or 'Contact Us' form on the Tech Serve Solutions website, providing your details and the product CAS number (189281-92-3).
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