4-Bromo-2-(trifluoromethyl)phenyl isocyanate
4-Bromo-2-(trifluoromethyl)phenyl isocyanate (CAS: 186589-12-8), with the molecular formula BrC6H3(CF3)NCO and a molecular weight of 266.01, is a vital organic building block. This isocyanate derivative is extensively utilised in chemical synthesis for the creation of diverse organic compounds. Its reactive isocyanate group readily participates in addition reactions, making it a valuable intermediate in the development of pharmaceuticals and advanced materials.
Intermediate in Organic Synthesis
Serves as a key building block in the synthesis of complex organic molecules. Its trifluoromethyl and bromo substituents offer unique reactivity and allow for the introduction of specific functionalities into target compounds.
Pharmaceutical Research and Development
Utilised in the development of novel pharmaceutical agents. The isocyanate moiety can be incorporated into various heterocyclic systems or used to create urea and carbamate linkages, which are common in drug structures.
Materials Science
Can be employed in the synthesis of specialty polymers and functional materials. The presence of fluorine and bromine can impart desirable properties such as thermal stability and altered electronic characteristics to the resulting materials.
| Molecular weight | 266.01 |
|---|---|
| Linear formula | BrC6H3(CF3)NCO |
| Assay | 96% |
| Boiling point | 115 °C/10 mmHg(lit.) |
| Density | 1.699 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.524(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromo-2-(trifluoromethyl)phenyl isocyanate used for?
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4-Bromo-2-(trifluoromethyl)phenyl isocyanate is primarily used as a versatile building block in organic synthesis, particularly in the research and development of pharmaceuticals and advanced materials due to its reactive isocyanate group and specific aromatic substitution pattern.
What are the CAS number and formula for this compound?
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The CAS number is 186589-12-8 and the molecular formula is BrC6H3(CF3)NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Bromo-2-(trifluoromethyl)phenyl isocyanate with an assay of 96%. We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
What are the primary safety hazards associated with this chemical?
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This compound is classified as harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation, and may cause respiratory irritation (H302, H312, H315, H319, H332, H335). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator, must be used.
Is this product available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, including 4-Bromo-2-(trifluoromethyl)phenyl isocyanate.
How can I request a quote or sample?
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To request a quote or a sample of 4-Bromo-2-(trifluoromethyl)phenyl isocyanate, please contact our sales team through the website or by phone.
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