4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester
4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester (CAS: 146998-31-4; Formula: C19H18N4O4; MW: 366.37) is a valuable biochemical reagent. It is employed for labeling proteins and peptides via their amino groups, forming stable linkages. This compound is recognised for its utility as a long-wavelength quencher and an acceptor chromophore in Förster Resonance Energy Transfer (FRET) studies due to its distinct absorption characteristics.
- IUPAC
- 4-(Dimethylamino)azobenzene-4′-carboxylic acid N-succinimidyl ester,DABCYL-N-succinimidyl ester
![4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester (C19H18N4O4) — chemical structure, CAS 146998-31-4; Life Science, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F146998-31-4.png&w=3840&q=75)
Protein and Peptide Labelling
This succinimidyl ester reacts with terminal amines and lysine residues in proteins and peptides, enabling the introduction of a chromophore for various analytical purposes. It is particularly useful for fluorescent studies and modifications.
FRET Studies
The compound functions as an effective long-wavelength quencher and acceptor chromophore in Förster Resonance Energy Transfer (FRET) assays. Its spectral properties are well-suited for energy transfer investigations between molecules.
Biochemical Reagent
As a versatile biochemical reagent, it serves in diverse research applications requiring specific chemical modifications and detection capabilities, particularly within biological systems.
| Molecular weight | 366.37 |
|---|---|
| Empirical formula | C19H18N4O4 |
| Assay | ≥98.0% (HPLC) |
| Solubility | DMF: solubleDMSO: soluble |
| Storage temperature | −20°C |
| Application | A useful reagent (similar to MANCYL-SE) for labeling proteins or peptides through their amino-groups by forming stable peptide bonds. The succinimidyl ester is reactive with terminal amines or lysines of peptides and other nucleophiles for fluorescent studies of proteins. Its fluorescent properties (has a characteristic broad and intense visible absorption but has no fluorescence) make it an ideal long wavelength quencher and it has been utilized as an acceptor chromophore in FRET studies.1,2 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 428 nm; λem 453 nm |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester used for?
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This compound is used for labelling proteins and peptides via their amino groups, forming stable linkages. It also serves as a long-wavelength quencher and an acceptor chromophore in FRET studies.
What is the CAS number and molecular formula for this product?
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The CAS number is 146998-31-4 and the molecular formula is C19H18N4O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with a purity of ≥98.0% (HPLC). We do not represent it as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should 4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It is classified under WGK Germany 3.
How is this chemical packed, shipped, and exported?
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This chemical is typically stored at -20°C. TSS is a specialist global supplier and exporter of fine chemicals, ensuring secure and compliant packaging and international shipment.
How can I request a sample or quote?
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Please contact our sales team through our website or by phone to request a sample or a detailed quotation for 4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester.
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