3-Methyladenine

CAS 5142-23-4C6H7N5Biochemicals & Reagents

3-Methyladenine (CAS: 5142-23-4), a purine derivative with the formula C6H7N5 and a molecular weight of 149.15 g/mol, is a biochemical reagent primarily utilised for its role in the study of autophagy. It acts as an inhibitor of this cellular process by impeding autophagosome formation through the inhibition of phosphatidylinositol 3-kinases (PI-3K). This compound is essential for researchers investigating cellular degradation pathways and related biological mechanisms.

IUPAC: 3-MA,6-Amino-3-methylpurine

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3-Methyladenine (C6H7N5) — chemical structure, CAS 5142-23-4; Life Science, fine chemical supplied by Tech Serve Solutions

AutophagyAutophagy InhibitorsBiochemicals and ReagentsCell BiologyCore BioreagentsNucleoside AnalogsNucleosides and NucleotidesNucleosidesNucleotidesOligonucleotides

01 /Applications

Autophagy Inhibition Studies

3-Methyladenine serves as a key tool for investigating the mechanism and regulation of autophagy. It effectively inhibits autophagosome formation by targeting type III PI-3K, allowing researchers to study the downstream effects of autophagy disruption in various cellular models.

Cellular Mechanism Research

Utilised in cell biology and signalling research, 3-Methyladenine aids in elucidating the complex roles of autophagy in cellular homeostasis, apoptosis, and response to stress. Its specific inhibitory action provides a controlled method for exploring these pathways.

Biochemical Reagent

As a biochemical reagent, 3-Methyladenine is supplied for laboratory use, supporting a wide range of research applications within molecular biology, cell biology, and neuroscience.

02 /Properties

Molecular weight	149.15
Empirical formula	C6H7N5
Application	3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
Melting point	~300 °C (dec.)(lit.)

03 /Identifiers & registry

CAS number

5142-23-4

MDL number

MFCD00010531

PubChem substance

24897326

Beilstein registry

146087

04 /Additional specifications

Quality Level	PREMIUM

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 3-Methyladenine used for?

3-Methyladenine is primarily used as an inhibitor to study the mechanism of autophagy, a cellular degradation process. It works by blocking autophagosome formation through the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). It is typically used at a concentration of 5 mM for this purpose.

What are the CAS number and formula for 3-Methyladenine?

The CAS number for 3-Methyladenine is 5142-23-4, and its empirical formula is C6H7N5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 3-Methyladenine at a PREMIUM quality level. TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.

What are the safety and handling considerations for 3-Methyladenine?

3-Methyladenine is classified under WGK Germany 3, indicating a high hazard to water. Appropriate personal protective equipment should be used, and handling should occur in a well-ventilated area to avoid exposure. Refer to the safety data sheet for comprehensive handling and disposal information.

How is 3-Methyladenine packed, shipped, and exported?

3-Methyladenine is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations for chemical compounds.

How can I request a sample or a quote for 3-Methyladenine?

To request a sample or a quote for 3-Methyladenine, please contact our sales team via the website or direct inquiry channels, providing your specific requirements and contact details.