3-Methyl-L-histidine
3-Methyl-L-histidine (CAS 368-16-1) is a modified amino acid with the molecular formula C7H11N3O2 and a molecular weight of 169.18 g/mol. This compound serves as a valuable building block in biochemical research and plays a role in protein metabolism. Its structure, an isomer of histidine, makes it an important tool for investigating enzyme mechanisms and cellular processes. It is supplied by TSS for laboratory and research applications.
- IUPAC
- π-Methyl-L-histidine,1-Methyl-L-histidine (archaic),3-(1-Methylimidazol-5-yl)-L-alanine
- Synonyms
- 3-(1-Methylimidazol-5-yl)-L-alanineπ-Methyl-L-histidine1-Methyl-L-histidine (archaic)

Biochemical Research
3-Methyl-L-histidine is utilised in various biochemical studies, particularly those involving protein structure and function. Its unique chemical properties allow researchers to probe enzymatic pathways and metabolic processes.
Peptide Synthesis
As a modified amino acid, it can be incorporated into synthetic peptides to investigate their biological activity or stability. This aids in the development of novel therapeutic agents or research tools.
Metabolic Pathway Studies
The compound is used to study specific metabolic pathways related to amino acid metabolism and protein turnover. Researchers employ it to understand the biochemical significance of histidine modification.
| Molecular weight | 169.18 |
|---|---|
| Empirical formula | C7H11N3O2 |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Methyl-L-histidine used for?
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3-Methyl-L-histidine is primarily used in biochemical research, peptide synthesis, and studies of metabolic pathways. It serves as a modified amino acid for investigating protein structure, function, and cellular processes.
What are the CAS number and formula for 3-Methyl-L-histidine?
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The CAS number for 3-Methyl-L-histidine is 368-16-1, and its empirical formula is C7H11N3O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Methyl-L-histidine for research purposes. The specific purity and grade available can be confirmed by checking the product's Certificate of Analysis or by contacting our sales team. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should 3-Methyl-L-histidine be handled?
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Handle 3-Methyl-L-histidine with appropriate personal protective equipment, including a dust mask (type N95 recommended), eyeshields, and gloves. Ensure adequate ventilation, as it may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335).
How is 3-Methyl-L-histidine packaged and shipped?
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3-Methyl-L-histidine is carefully packaged to maintain its integrity during transit. TSS is an experienced global supplier and exporter, adhering to all relevant shipping regulations for chemical compounds.
How can I request a sample or quote for 3-Methyl-L-histidine?
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To request a sample or obtain a quote for 3-Methyl-L-histidine, please contact the TSS sales department via our website or direct email, providing your specific requirements.
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