2′-Deoxyuridine 5′-monophosphate disodium salt

CAS 42155-08-8C9H11N2O8PNa2Cell Biology

2′-Deoxyuridine 5′-monophosphate disodium salt (CAS 42155-08-8), with the molecular formula C9H11N2O8PNa2 and a molar mass of 352.15 g/mol, is a crucial deoxynucleotide monophosphate. It serves as the substrate for thymidylate synthetase in the de novo synthesis of dTMP. This compound is utilised in biochemical research for studying nucleotide metabolism and as a reference substrate for evaluating potential chemotherapy agents targeting thymidylate synthetase.

IUPAC: dUMP

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2′-Deoxyuridine 5′-monophosphate disodium salt (C9H11N2O8PNa2) — chemical structure, CAS 42155-08-8; Life Science, fine chemical supplied by Tech Serve Solutions

Cell BiologyMetabolic PathwaysMetabolomicsNucleotide

01 /Applications

Enzyme Substrate in Nucleotide Synthesis

2′-Deoxyuridine 5′-monophosphate disodium salt functions as the natural substrate for the enzyme thymidylate synthetase (TS). This enzyme is essential for the de novo production of deoxythymidine monophosphate (dTMP), a key component of DNA.

Research in Cancer Chemotherapy

This compound is employed as a reference substrate in the investigation of dUMP analogues. These analogues are studied for their potential as chemotherapeutic agents, particularly those that inhibit thymidylate synthetase activity.

Metabolic Pathway Studies

Utilised in cell biology and metabolomics research, it aids in understanding nucleotide metabolism and related metabolic pathways. Its role in the synthesis of dTMP makes it valuable for studying nucleotide homeostasis.

02 /Properties

Molecular weight	352.15
Linear formula	C9H11N2O8PNa2
Storage temperature	−20°C
Application	2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22-36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

42155-08-8

MDL number

MFCD00065282

PubChem substance

24893787

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2′-Deoxyuridine 5′-monophosphate disodium salt used for?

2′-Deoxyuridine 5′-monophosphate disodium salt is used as a substrate for thymidylate synthetase in the de novo production of dTMP and as a reference substrate in studies of dUMP analogues for potential chemotherapy applications.

What are the CAS number and molecular formula?

The CAS number is 42155-08-8 and the molecular formula is C9H11N2O8PNa2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product for research and laboratory use. The specific assay and purity details are available on the product's Certificate of Analysis. TSS does not represent this product as USP, BP, or EP grade.

How should 2′-Deoxyuridine 5′-monophosphate disodium salt be handled?

Handle with appropriate personal protective equipment including a dust mask (type N95 US), eyeshields, and gloves. Avoid breathing dust. This compound is harmful if swallowed and may cause skin, eye, and respiratory irritation.

How is this chemical packed and shipped?

Products are carefully packed in appropriate containers for secure transport and are exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations.

How can I request a sample or quote?

Please use the 'Request a Quote' or 'Request a Sample' form on our website, providing the product name and CAS number, or contact our sales team directly.