2-Cyclopentylphenol
2-Cyclopentylphenol (CAS: 1518-84-9), with the molecular formula C11H16O and a molecular weight of 162.23 g/mol, is a valuable organic building block. This phenol derivative serves as a key intermediate in the synthesis of complex organic molecules, including pharmaceutical agents. Its primary utility lies in its application as a precursor for creating optically active compounds and other specialised chemical entities.
Synthesis of Optically Active Penbutolol
2-Cyclopentylphenol is employed in the synthesis of optically active (S)-penbutolol, an antihypertensive drug. This transformation is typically achieved via methods such as Sharpless asymmetric dihydroxylation, highlighting its role in chiral synthesis.
Intermediate for Pharmaceutical Synthesis
The compound serves as a crucial intermediate in the preparation of various pharmaceutical agents. It has been used in the synthesis of (S)-1-(2,3-epoxypropoxy)-2-chloro-5-methyl-benzene, demonstrating its versatility in medicinal chemistry.
Organic Building Block
As an organic building block, 2-Cyclopentylphenol is utilized in general chemical synthesis for the construction of more complex molecular structures. Its phenolic hydroxyl group and cyclopentyl substituent offer reactive sites for diverse chemical transformations.
| Molecular weight | 162.23 |
|---|---|
| Linear formula | C5H9C6H4OH |
| Assay | 95% |
| Grade | technical grade |
| Boiling point | 148-150 °C/18 mmHg(lit.) |
| Refractive index | n20/D 1.555(lit.) |
| Application | 2-Cyclopentylphenol has been used in the synthesis of:• optically active (S)-penbutolol (antihypertensive drug) via Sharpless asymmetric dihydroxylation1• (S)-1-(2,3-epoxypropoxy)-2-chloro-5-methyl-benzene2 |
| Melting point | 34-35 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... GABRA1(2554) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Cyclopentylphenol used for?
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2-Cyclopentylphenol is primarily used as an intermediate in organic synthesis, particularly for the preparation of optically active compounds such as (S)-penbutolol and other pharmaceutical agents. It also functions as a general organic building block.
What is the CAS number and chemical formula for 2-Cyclopentylphenol?
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The CAS number for 2-Cyclopentylphenol is 1518-84-9, and its linear chemical formula is C5H9C6H4OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Cyclopentylphenol in technical grade with an assay of 95%. This product is not represented as USP, BP, or EP grade.
How should 2-Cyclopentylphenol be handled safely?
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2-Cyclopentylphenol is a warning-classified substance (GHS07) causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, must be worn. Handle in a well-ventilated area and avoid breathing dust.
Is 2-Cyclopentylphenol a controlled substance?
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Based on the provided data, there is no indication that 2-Cyclopentylphenol is a controlled substance.
How is 2-Cyclopentylphenol packed, shipped, and exported?
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Tech Serve Solutions specialises in the global supply and export of fine chemicals, including 2-Cyclopentylphenol, adhering to all necessary international shipping and handling regulations.
How can I request a quote or sample for 2-Cyclopentylphenol?
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To request a quote or a sample of 2-Cyclopentylphenol, please contact the Tech Serve Solutions sales team through our official channels.
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