3-Hydroxy-4-methoxybenzaldehyde
3-Hydroxy-4-methoxybenzaldehyde (CAS: 621-59-0, Formula: HOC6H3(OCH3)CHO, Molar Mass: 152.15 g/mol) is a key organic intermediate. This aromatic aldehyde, also known as isovanillin, is characterised by its hydroxy and methoxy substituents on the benzaldehyde core. It serves as a valuable building block in organic synthesis, notably employed in the stereoselective synthesis of potent anticancer agents and in the preparation of natural product derivatives.
- IUPAC
- 3-Hydroxyanisaldehyde,Isovanillin
- Synonyms
- 3-HydroxyanisaldehydeIsovanillin
Anticancer Drug Synthesis
3-Hydroxy-4-methoxybenzaldehyde is a critical starting material in the multi-step synthesis of combretastatin A-4, a compound with significant antineoplastic properties, demonstrating its utility in pharmaceutical research and development.
Natural Product Synthesis
This compound has been utilised as a precursor in the synthesis of various natural products, including glycitein, a plant isoflavone, highlighting its role in the preparation of biologically active molecules.
Organic Synthesis Building Block
As a functionalised benzaldehyde, 3-Hydroxy-4-methoxybenzaldehyde is a versatile building block for constructing more complex organic molecules. Its reactivity allows for diverse chemical transformations.
| Molecular weight | 152.15 |
|---|---|
| Linear formula | HOC6H3(OCH3)CHO |
| Assay | 99% |
| Boiling point | 179 °C/15 mmHg(lit.) |
| Application | 3-Hydroxy-4-methoxybenzaldehyde was used as starting reagent during the two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin A-41 and glycitein synthesis2. |
| Melting point | 113-115 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Hydroxy-4-methoxybenzaldehyde used for?
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3-Hydroxy-4-methoxybenzaldehyde is primarily used as a starting material in organic synthesis, particularly for the preparation of pharmaceuticals like (Z)-combretastatin A-4 and natural products such as glycitein.
What are the CAS number and chemical formula for 3-Hydroxy-4-methoxybenzaldehyde?
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The CAS number is 621-59-0, and the chemical formula is HOC6H3(OCH3)CHO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Hydroxy-4-methoxybenzaldehyde with a purity of 99%. This product is suitable for research and chemical synthesis purposes. We do not represent it as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should 3-Hydroxy-4-methoxybenzaldehyde be handled?
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3-Hydroxy-4-methoxybenzaldehyde is classified as a Warning substance. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (US N95), eyeshields, and gloves, should be used during handling.
How is 3-Hydroxy-4-methoxybenzaldehyde packed and exported?
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Tech Serve Solutions expertly packs and exports fine chemicals globally, ensuring product integrity and compliance with international shipping regulations.
How can I request a sample or quote for 3-Hydroxy-4-methoxybenzaldehyde?
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To request a sample or a quotation for 3-Hydroxy-4-methoxybenzaldehyde, please contact our sales team via the website or direct email.
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