Chlorothiazide

CAS 58-94-6C7H6ClN3O4S2Biochemicals & Reagents

Chlorothiazide (CAS: 58-94-6, Formula: C7H6ClN3O4S2, Molecular Weight: 295.72) is a thiazide diuretic, an early member of this drug class. It functions by increasing the excretion of sodium while sparing calcium. This compound is recognised for its role in influencing ion transport and is an inhibitor of carbonic anhydrase.

IUPAC: 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

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Chlorothiazide (C7H6ClN3O4S2) — chemical structure, CAS 58-94-6; Life Science, fine chemical supplied by Tech Serve Solutions

A to CBioactive Small MoleculesBiochemicals and ReagentsC-CHCarbonic anhydraseCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitors

01 /Applications

Diuretic Agent

Chlorothiazide is a thiazide diuretic used to treat edema associated with conditions like congestive heart failure and liver cirrhosis. Its mechanism involves inhibiting sodium reabsorption in the kidneys.

Calcium and Lithium Ion Balance

This compound exhibits a calcium-sparing effect, meaning it reduces the excretion of calcium in the urine. Conversely, it also influences lithium excretion, which is a clinically relevant consideration.

Carbonic Anhydrase Inhibition

Chlorothiazide acts as an inhibitor of carbonic anhydrase, an enzyme involved in various physiological processes, including fluid balance and acid-base regulation.

02 /Properties

Molecular weight	295.72
Empirical formula	C7H6ClN3O4S2
Storage temperature	2-8°C
Application	One of the first in the thiazide class of diuretics. The effect is sparing of calcium1 and lithium2, but increases the excretion of sodium.1

03 /Safety & handling

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms if inhaled

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P280Wear protective gloves, clothing and eye/face protection
P342

Protective equipment	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Water hazard class (WGK, DE)	2
Hazard codes (EU)	Xn
Risk statements (R)	42/43
Safety statements (S)	36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

58-94-6

MDL number

MFCD00058576

PubChem substance

24278150

05 /Additional specifications

Gene Information	human ... CA1(759), CA4(762), SLC12A3(6559)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Chlorothiazide used for?

Chlorothiazide is primarily used as a diuretic to treat edema and as a carbonic anhydrase inhibitor. It is known for its calcium-sparing and lithium-influencing properties.

What is the CAS number and formula for Chlorothiazide?

The CAS number for Chlorothiazide is 58-94-6 and its empirical formula is C7H6ClN3O4S2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Chlorothiazide typically as a research or technical grade chemical. We do not represent it as USP, BP, or EP grade unless explicitly stated in the product specifications.

How should Chlorothiazide be handled safely?

Chlorothiazide is classified with a 'Danger' signal word. It may cause an allergic skin reaction (H317) and if inhaled, may cause allergy or asthma symptoms or breathing difficulties (H334). Appropriate PPE, including a dust mask (N95), eyeshields, face shields, and gloves, is essential during handling. Avoid breathing dust.