3-Fluoro-4-methylaniline
3-Fluoro-4-methylaniline (CAS: 452-77-7), with the molecular formula FC6H3(CH3)NH2 and a molecular weight of 125.14 g/mol, is a fluorinated aromatic amine. This compound serves as a valuable building block in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals where the introduction of fluorine can modulate biological activity. Its structure allows for diverse chemical transformations, making it a key intermediate for creating complex molecules.
- IUPAC
- 3-Fluoro-p-toluidine,4-Amino-2-fluorotoluene
- Synonyms
- 3-Fluoro-p-toluidine4-Amino-2-fluorotoluene
Pharmaceutical Intermediate
3-Fluoro-4-methylaniline is utilised as a key building block in the synthesis of active pharmaceutical ingredients (APIs). The presence of the fluorine atom can enhance metabolic stability and binding affinity of drug candidates.
Agrochemical Development
This compound finds application in the research and development of new agrochemicals. Fluorinated aromatic amines are often incorporated into pesticides and herbicides to improve efficacy and environmental persistence profiles.
Specialty Chemical Synthesis
As a versatile organic building block, 3-Fluoro-4-methylaniline is employed in the synthesis of various specialty chemicals and advanced materials where specific fluorinated aromatic structures are required.
| Molecular weight | 125.14 |
|---|---|
| Linear formula | FC6H3(CH3)NH2 |
| Assay | 99% |
| Density | 1.093 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.54(lit.) |
| Melting point | 30-32 °C(lit.) |
Hazard statements
- H300Fatal if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 89 °C / 192.2 °F |
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluoro-4-methylaniline used for?
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3-Fluoro-4-methylaniline is primarily used as a building block in organic synthesis, particularly for the development of pharmaceuticals, agrochemicals, and other specialty chemicals. Its fluorinated aromatic structure makes it valuable for introducing specific properties into target molecules.
What is the CAS number and chemical formula for 3-Fluoro-4-methylaniline?
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The CAS number for 3-Fluoro-4-methylaniline is 452-77-7, and its linear chemical formula is FC6H3(CH3)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Fluoro-4-methylaniline with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for 3-Fluoro-4-methylaniline?
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3-Fluoro-4-methylaniline is classified as dangerous. It is harmful if swallowed, in contact with skin, and if inhaled. It also causes skin and serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and suitable respiratory protection, should be used. Ensure adequate ventilation. Refer to the Safety Data Sheet for detailed handling information.
How is 3-Fluoro-4-methylaniline packed and shipped?
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3-Fluoro-4-methylaniline is packed and shipped according to international regulations for hazardous materials, including UN 2811 classification. We export globally, ensuring compliance with all relevant shipping and customs requirements.
How can I request a quote or sample for 3-Fluoro-4-methylaniline?
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To request a quote or sample of 3-Fluoro-4-methylaniline, please contact our sales team through the website or by phone. Provide your contact details and the quantity required.
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