3-Fluoro-4-methoxyphenylmagnesium bromide
3-Fluoro-4-methoxyphenylmagnesium bromide (CAS: 112780-67-3), with the linear formula FC₆H₃(OCH₃)MgBr and a molecular weight of 229.33 g/mol, is a versatile Grignard reagent. It is a key organometallic intermediate used in organic synthesis for introducing the 3-fluoro-4-methoxyphenyl group into various molecules. Its applications span pharmaceutical research and fine chemical manufacturing, facilitating the creation of complex organic structures.
Organometallic Synthesis
As a Grignard reagent, it is extensively used in carbon-carbon bond formation reactions, acting as a nucleophile to react with electrophiles like aldehydes, ketones, esters, and epoxides.
Pharmaceutical Intermediate
This compound serves as a crucial building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), enabling the precise introduction of fluorinated and methoxy-substituted phenyl rings.
Fine Chemical Production
It is employed in the synthesis of advanced materials and specialty chemicals where specific aryl substitution patterns are required.
| Molecular weight | 229.33 |
|---|---|
| Linear formula | FC6H3(OCH3)MgBr |
| Boiling point | 65 °C(lit.) |
| Density | 0.964 g/mL at 25 °C(lit.) |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluoro-4-methoxyphenylmagnesium bromide used for?
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3-Fluoro-4-methoxyphenylmagnesium bromide is primarily used as a Grignard reagent in organic synthesis for carbon-carbon bond formation, serving as an intermediate in the production of pharmaceuticals and fine chemicals.
What is the CAS number and formula for this compound?
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The CAS number is 112780-67-3, and its linear formula is FC₆H₃(OCH₃)MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a concentration of 0.5 M in THF. We do not represent this product as USP, BP, or EP grade.
How should 3-Fluoro-4-methoxyphenylmagnesium bromide be handled?
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This is a flammable liquid and vapour that causes serious eye irritation and may cause respiratory irritation. It may also cause cancer. Handle in a well-ventilated area, away from ignition sources. Wear appropriate personal protective equipment, including gloves, eye protection, and respiratory protection. Due to its reactivity, it may form explosive peroxides; store under refrigeration and follow safe handling procedures for peroxidisable compounds.
Is this compound shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, including 3-Fluoro-4-methoxyphenylmagnesium bromide.
How can I request a sample or quote?
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To request a sample or quote for 3-Fluoro-4-methoxyphenylmagnesium bromide, please contact our sales team through the website or by phone.
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