3-Fluoro-4-methoxyphenylboronic acid

CAS 149507-26-6FC6H3(OCH3)B(OH)2Chemical Synthesis

3-Fluoro-4-methoxyphenylboronic acid (CAS: 149507-26-6; Formula: C7H8BFO3; MW: 169.95) is a key aryl boronic acid derivative utilised in organic synthesis. It serves as a versatile building block in cross-coupling reactions, including Suzuki couplings, and is instrumental in the preparation of complex organic molecules. Its specific substitution pattern makes it valuable for introducing fluorinated and methoxylated phenyl groups in drug discovery and material science research.

IUPAC: 3-Fluoro-4-methoxybenzeneboronic acid,3-Fluoro-4-methyloxyphenylboronic acid,4-Methoxy-3-fluorophenylboronic acid
Synonyms: 3-Fluoro-4-methoxybenzeneboronic acid4-Methoxy-3-fluorophenylboronic acid

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3-Fluoro-4-methoxyphenylboronic acid (FC6H3(OCH3)B(OH)2) — chemical structure, CAS 149507-26-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Synthesis of Hydroxyphenylnaphthols

Acts as a reactant in the preparation of hydroxyphenylnaphthols. These compounds have been investigated as inhibitors for 17ß-hydroxysteroid dehydrogenase Type 2.

Regioselective Suzuki Coupling

A valuable reagent for performing regioselective Suzuki coupling reactions. This enables the precise formation of carbon-carbon bonds in the synthesis of complex organic structures.

Arylation Reactions

Utilised in ruthenium-catalyzed arylation reactions. This application is important for the efficient introduction of aryl groups onto various substrates.

Synthesis of Potential Antitumors

Employed in the synthesis of amino-trimethoxyphenyl-aryl thiazoles. These molecules have shown potential as microtubule inhibitors with antitumour activity.

Rhodium Catalyzed Cyanation

Serves as a reactant in rhodium-catalyzed cyanation reactions, facilitating the introduction of nitrile groups into organic molecules.

Petasis Reaction

Can participate in the Petasis reaction, a multi-component reaction used for the synthesis of amines and other organic compounds.

02 /Properties

Molecular weight	169.95
Linear formula	FC6H3(OCH3)B(OH)2
Application	Reactant for:• Preparation of hydroxyphenylnaphthols as 17ß-hydroxysteroid dehydrogenase Type 2 inhibitors1• Regioselective Suzuki coupling2• Ruthenium-catalyzed arylation reactions3• Synthesis of amino-trimethoxyphenyl-aryl thiazoles as microtubule inhibitors and potential antitumors4• Rhodium catalyzed cyanation5• Petasis reaction6
Melting point	206-211 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

149507-26-6

MDL number

MFCD00807404

PubChem substance

24880146

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 3-Fluoro-4-methoxyphenylboronic acid used for?

3-Fluoro-4-methoxyphenylboronic acid is used as a reactant in various organic synthesis applications, including regioselective Suzuki couplings, arylation reactions, and the preparation of biologically active compounds like hydroxyphenylnaphthols and potential antitumour agents.

What are the CAS number and molecular formula for this compound?

The CAS number is 149507-26-6, and the molecular formula is C7H8BFO3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical for research and development purposes. The specific assay or grade available may vary; please contact us for current specifications. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.

What are the main hazards associated with 3-Fluoro-4-methoxyphenylboronic acid?

This compound may cause skin irritation, serious eye irritation, and respiratory irritation. Always handle with appropriate personal protective equipment, including eyeshields and gloves, and ensure adequate ventilation. Consult the Safety Data Sheet (SDS) for comprehensive hazard information.

How is 3-Fluoro-4-methoxyphenylboronic acid packed and shipped?

Tech Serve Solutions carefully packages and exports fine chemicals globally. Packaging is designed to maintain product integrity during transit. Please contact us for specific shipping and export inquiries.

How can I request a sample or quote?

To request a sample or obtain a quotation for 3-Fluoro-4-methoxyphenylboronic acid, please use the 'Request Quote' or 'Request Sample' buttons on our website, or contact our sales team directly.