3-Chloro-4-methylphenylzinc iodide solution
3-Chloro-4-methylphenylzinc iodide solution (CAS: 352525-66-7; Formula: ClC6H3(CH3)ZnI; MW: 317.87) is an organozinc halide reagent. Supplied as a 0.5 M solution in THF, it is primarily utilised in organic synthesis for carbon-carbon bond formation via cross-coupling reactions. This arylzinc iodide offers a versatile tool for introducing the 3-chloro-4-methylphenyl moiety into complex molecular structures, finding utility in pharmaceutical and fine chemical research and development.
Cross-Coupling Reactions
This organozinc reagent serves as a key nucleophile in transition-metal catalysed cross-coupling reactions, such as Negishi coupling. It enables the efficient formation of new carbon-carbon bonds by reacting with various organic electrophiles.
Aryl Group Transfer
It is employed for the selective transfer of the 3-chloro-4-methylphenyl group. This is particularly useful in the synthesis of complex organic molecules where precise introduction of substituted aryl moieties is required.
Intermediate Synthesis
Used in the multi-step synthesis of advanced intermediates for pharmaceuticals and agrochemicals. The specific substitution pattern of the aryl group can be crucial for the biological activity of the final product.
| Molecular weight | 317.87 |
|---|---|
| Linear formula | ClC6H3(CH3)ZnI |
| Density | 1.026 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
| Impurities tested | 1-3% inorganic chloride |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2056 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloro-4-methylphenylzinc iodide solution used for?
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3-Chloro-4-methylphenylzinc iodide solution (CAS: 352525-66-7) is used in organic synthesis, particularly in transition-metal catalysed cross-coupling reactions for carbon-carbon bond formation and aryl group transfer.
What are the CAS number and formula for this product?
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The CAS number is 352525-66-7 and the linear formula is ClC6H3(CH3)ZnI.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF containing 1-3% inorganic chloride impurities. TSS does not represent this product as USP, BP, or EP grade.
How should 3-Chloro-4-methylphenylzinc iodide solution be handled?
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This product is highly flammable (flash point -17 °C) and may form explosive peroxides. It is also a skin, eye, and respiratory irritant. Handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources, and store refrigerated at 2-8°C.
Is this chemical shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates and laboratory reagents.
How can I request a sample or quote?
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Please contact our sales department through the website or by phone to request a sample or a formal quotation for 3-Chloro-4-methylphenylzinc iodide solution.
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