Diphenyl(2-methoxyphenyl)phosphine
Diphenyl(2-methoxyphenyl)phosphine (CAS: 53111-20-9) is an organophosphorus compound with the linear formula (C6H5)2PC6H4OCH3 and a molecular weight of 292.31 g/mol. This phosphine ligand is valuable in organic synthesis, particularly for catalytic applications such as cross-coupling reactions. Supplied at 98% purity, it serves as a key intermediate and reagent for researchers and chemical manufacturers.
- IUPAC
- (2-Methoxyphenyl)diphenylphosphine,(o-Methoxyphenyl)diphenylphosphine,2-(Diphenylphosphino)anisole,Diphenyl(o-anisyl)phosphine,Diphenyl(o-methoxyphenyl)phosphine
- Synonyms
- 2-(Diphenylphosphino)anisole(2-Methoxyphenyl)diphenylphosphineDiphenyl(o-anisyl)phosphineDiphenyl(o-methoxyphenyl)phosphine

Catalysis and Cross-Coupling Reactions
This phosphine ligand is extensively used in transition metal-catalyzed cross-coupling reactions, facilitating the formation of carbon-carbon and carbon-heteroatom bonds. Its electronic and steric properties make it effective in promoting various coupling methodologies.
Chemical Synthesis Intermediate
As a versatile organophosphorus compound, it serves as an important building block in the synthesis of more complex molecules. It is employed in the preparation of novel ligands, organometallic complexes, and functional materials.
Ligand Design
Diphenyl(2-methoxyphenyl)phosphine can be used directly as a ligand or as a precursor for the synthesis of more sophisticated phosphine ligands with tailored properties for specific catalytic processes.
| Molecular weight | 292.31 |
|---|---|
| Linear formula | (C6H5)2PC6H4OCH3 |
| Assay | 98% |
| Melting point | 124-126 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diphenyl(2-methoxyphenyl)phosphine used for?
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Diphenyl(2-methoxyphenyl)phosphine is primarily used as a ligand in catalysis, especially for cross-coupling reactions, and as an intermediate in organic and inorganic chemical synthesis.
What is the CAS number and formula for Diphenyl(2-methoxyphenyl)phosphine?
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The CAS number is 53111-20-9, and its linear formula is (C6H5)2PC6H4OCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diphenyl(2-methoxyphenyl)phosphine with an assay of 98%. This product is suitable for research and technical applications; TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
How should Diphenyl(2-methoxyphenyl)phosphine be handled safely?
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Diphenyl(2-methoxyphenyl)phosphine is classified as a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). When handling, use a dust mask (type N95 recommended), wear eyeshields and gloves, and ensure adequate ventilation. Avoid breathing dust and handle in a well-ventilated area.
Is Diphenyl(2-methoxyphenyl)phosphine a controlled substance?
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Based on the provided data, Diphenyl(2-methoxyphenyl)phosphine is not listed as a controlled substance.
How is Diphenyl(2-methoxyphenyl)phosphine packed, shipped, and exported?
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Tech Serve Solutions offers expert packing, shipping, and global export services for Diphenyl(2-methoxyphenyl)phosphine, ensuring compliance with all relevant regulations for chemical transport.
How can I request a sample or a quote for Diphenyl(2-methoxyphenyl)phosphine?
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To request a sample or a quote, please contact our sales team via the website or direct inquiry, providing your contact details and the quantity required.
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